KSR2

kinase suppressor of ras 2

Summary

Enables protein serine/threonine kinase activity. Predicted to be involved in Ras protein signal transduction; calcium-mediated signaling; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants197 total

rsidPosition (GRCh37)AllelesClassClinVar
rs37061549212:117,905,018G/A—likely benign
rs1230488912:117,907,449C/T—benign
rs94337014612:117,907,457G/A—likely benign
rs76180075912:117,907,484A/G—likely benign
rs3452624312:117,907,503C/T—uncertain significance
rs5640710512:117,907,556A/G—benign
rs77314362912:117,907,611C/T—likely benign
rs20163702012:117,908,997G/A—likely benign
rs18340064112:117,909,032G/A—likely benign
rs54069103912:117,909,076G/A—uncertain significance
rs37720006212:117,909,113A/G—likely benign
rs37205808012:117,914,274G/A—likely benign
rs56585004712:117,914,319T/C—likely benign
rs36801027412:117,914,324C/T—uncertain significance
rs20214802512:117,914,325G/A—likely benign
rs77267179312:117,914,339G/A—uncertain significance
rs187179425312:117,914,364T/G—likely benign
rs76209123512:117,914,379G/A—likely benign
rs56814975412:117,914,398C/T—uncertain significance
rs37284512612:117,914,399G/A—uncertain significance
rs37704217312:117,914,403G/A—benign
rs18735411112:117,922,283G/A—likely benign
rs74696427012:117,922,334G/C—likely benign
rs1231801712:117,922,368G/C—benign
rs187235222112:117,922,372C/T—likely benign
rs36802700812:117,923,381G/A—likely benign
rs37476253912:117,923,392G/A—likely benign
rs37170238112:117,923,447C/T—uncertain significance
rs37719443512:117,923,463C/T—benign
rs36885230212:117,923,468C/T—uncertain significance
rs37365348912:117,923,469G/A—benign
rs77122583912:117,923,482C/T—uncertain significance
rs1282817212:117,928,182C/Tintron variant—
rs184664412:117,938,380T/Cintron variant—
rs160407912:117,938,519C/G——
rs476754912:117,950,252C/Tintron variant—
rs476755112:117,954,060C/G——
rs1077492912:117,955,027G/A——
rs111159912:117,956,032T/A——
rs213414312:117,956,422C/Tintron variant—
rs213414212:117,956,508T/C——
rs797492512:117,960,736G/Aintron variant—
rs77305180212:117,962,654G/T—likely benign
rs101045261012:117,962,667T/C—uncertain significance
rs14096006212:117,962,680C/T—likely benign
rs138752532912:117,962,699A/G—uncertain significance
rs75865506612:117,962,739C/T—uncertain significance
rs5635016112:117,962,761C/T—likely benign
rs54028677712:117,962,830G/A—likely benign
rs77132404312:117,962,871C/T—uncertain significance
rs5617840712:117,962,872G/A—benign
rs15016329612:117,962,876T/A—uncertain significance
rs75528874512:117,962,881C/G—uncertain significance
rs77227117712:117,962,936C/T—uncertain significance
rs56317564112:117,962,948C/T—uncertain significance
rs77607297012:117,963,001G/A—likely benign
rs37510711712:117,963,032C/T—uncertain significance
rs14785830512:117,963,033G/A—benign
rs76413521512:117,964,898A/G—uncertain significance
rs254206158412:117,968,744A/T—likely pathogenic
rs75462487012:117,968,754C/T—likely benign
rs74755779012:117,968,764G/A—uncertain significance
rs37596698612:117,968,784C/T—likely benign
rs54956486312:117,968,789G/A—uncertain significance
rs20015927912:117,968,793C/T—benign
rs74683822312:117,968,802C/T—likely benign
rs75135637912:117,968,803G/A—uncertain significance
rs76844049512:117,968,808C/T—likely benign
rs159296295212:117,969,461T/A—likely benign
rs76315253912:117,969,480T/C—uncertain significance
rs20100240612:117,969,481G/A—benign
rs1106853112:117,969,507G/A—benign
rs7899723212:117,977,504C/G—benign
rs254209769312:117,977,505T/G—likely benign
rs76793794312:117,977,546C/G—uncertain significance
rs5621483112:117,977,550T/C—likely benign
rs78171941712:117,977,557A/G—uncertain significance
rs139274032112:117,977,574A/G—uncertain significance
rs254209842912:117,977,576G/A—likely benign
rs37705402312:117,977,585C/T—likely benign
rs5569184512:117,977,588C/T—benign
rs5614362612:117,977,606G/T—likely benign
rs76237145412:117,977,618C/T—likely benign
rs37543010012:117,977,621G/A—likely benign
rs75314377612:117,977,627C/T—likely benign
rs75668871812:117,977,636C/T—likely benign
rs18574754312:117,977,639C/T—benign
rs254209925212:117,977,643G/A—uncertain significance
rs77230983112:117,977,645G/A—likely benign
rs37179508412:117,977,703A/G—benign
rs796415712:117,982,220C/Tintron variant—
rs54449982812:117,992,991T/C—uncertain significance
rs137736212812:117,993,030G/A—uncertain significance
rs56434772412:117,993,053T/C—uncertain significance
rs795580312:117,993,064C/A—likely benign
rs74911295012:117,993,070G/A—likely benign
rs18659813312:117,993,101G/A—likely benign
rs76923015312:117,993,103A/G—likely benign
rs77864338512:117,996,316C/T—uncertain significance
rs53127909312:117,996,323T/C—uncertain significance

Showing 100 of 197 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.