LIME1
Lck interacting transmembrane adaptor 1
Summary
This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Known Variants21 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2427533 | 20:62,365,866 | C/T | regulatory region variant | — |
| rs1221036716 | 20:62,368,912 | C/T | — | uncertain significance |
| rs758961506 | 20:62,368,978 | G/A | — | uncertain significance |
| rs777384373 | 20:62,369,178 | G/A | — | uncertain significance |
| rs578216847 | 20:62,369,181 | G/A | — | uncertain significance |
| rs775414822 | 20:62,369,208 | C/T | — | uncertain significance |
| rs765485708 | 20:62,369,215 | A/G | — | uncertain significance |
| rs572847837 | 20:62,369,230 | A/C | — | uncertain significance |
| rs751947812 | 20:62,369,239 | C/A | — | uncertain significance |
| rs781401062 | 20:62,369,244 | G/A | — | uncertain significance |
| rs753142248 | 20:62,369,251 | A/C | — | uncertain significance |
| rs914559 | 20:62,369,300 | C/A | — | — |
| rs1428798038 | 20:62,369,407 | A/G | — | uncertain significance |
| rs775769607 | 20:62,369,547 | G/A | — | uncertain significance |
| rs777505377 | 20:62,369,620 | C/G | — | uncertain significance |
| rs143622346 | 20:62,369,683 | C/T | — | uncertain significance |
| rs971974937 | 20:62,369,752 | C/T | — | uncertain significance |
| rs2517500862 | 20:62,369,787 | A/C | — | uncertain significance |
| rs533034221 | 20:62,370,165 | G/A | — | uncertain significance |
| rs760805241 | 20:62,370,221 | G/A | — | uncertain significance |
| rs1056441 | 20:62,370,349 | T/C | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.