LMTK2
lemur tyrosine kinase 2
Summary
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
Known Variants91 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1041561832 | 7:97,736,551 | C/T | — | uncertain significance |
| rs142486569 | 7:97,770,842 | A/G | — | uncertain significance |
| rs6977321 | 7:97,774,859 | A/G | intron variant | — |
| rs777312496 | 7:97,780,696 | G/A | — | uncertain significance |
| rs751573329 | 7:97,784,103 | G/A | — | uncertain significance |
| rs374467008 | 7:97,784,118 | G/A | — | uncertain significance |
| rs34320230 | 7:97,785,500 | C/T | intron variant | — |
| rs767662652 | 7:97,788,723 | G/C | — | uncertain significance |
| rs17169406 | 7:97,788,809 | T/C | intron variant | — |
| rs780921798 | 7:97,800,892 | A/T | — | uncertain significance |
| rs755759182 | 7:97,800,896 | G/C | — | uncertain significance |
| rs2535052527 | 7:97,800,937 | G/C | — | uncertain significance |
| rs760284569 | 7:97,814,404 | A/G | — | uncertain significance |
| rs1194450514 | 7:97,816,300 | A/G | — | uncertain significance |
| rs6465657 | 7:97,816,327 | C/T | regulatory region variant | — |
| rs6465658 | 7:97,816,638 | G/T | — | — |
| rs751988121 | 7:97,820,075 | A/G | — | uncertain significance |
| rs755345580 | 7:97,820,076 | T/G | — | uncertain significance |
| rs773235052 | 7:97,820,109 | A/C | missense variant | — |
| rs200541325 | 7:97,820,973 | C/T | — | uncertain significance |
| rs1797527414 | 7:97,821,035 | G/A | — | uncertain significance |
| rs750890663 | 7:97,821,139 | G/A | — | likely benign |
| rs147940573 | 7:97,821,227 | G/A | — | uncertain significance |
| rs764027277 | 7:97,821,246 | G/T | — | uncertain significance |
| rs200885902 | 7:97,821,335 | G/A | — | uncertain significance |
| rs1273781150 | 7:97,821,482 | C/T | — | uncertain significance |
| rs759441688 | 7:97,821,521 | A/T | — | uncertain significance |
| rs144529786 | 7:97,821,662 | G/A | — | uncertain significance |
| rs755548664 | 7:97,821,698 | A/G | — | uncertain significance |
| rs1212540082 | 7:97,821,716 | A/G | — | uncertain significance |
| rs1347577048 | 7:97,821,734 | G/A | — | uncertain significance |
| rs192651819 | 7:97,821,749 | A/G | — | uncertain significance |
| rs774194399 | 7:97,821,752 | G/A | — | uncertain significance |
| rs202036044 | 7:97,821,764 | G/A | — | uncertain significance |
| rs201290124 | 7:97,821,824 | G/A | — | uncertain significance |
| rs142723294 | 7:97,821,872 | C/T | — | uncertain significance |
| rs965524724 | 7:97,821,924 | T/C | — | uncertain significance |
| rs1797549718 | 7:97,821,967 | C/G | — | uncertain significance |
| rs145315793 | 7:97,822,059 | C/T | — | uncertain significance |
| rs1562921047 | 7:97,822,151 | G/A | — | uncertain significance |
| rs1293113256 | 7:97,822,168 | G/A | — | uncertain significance |
| rs138027258 | 7:97,822,268 | C/G | — | uncertain significance |
| rs56196840 | 7:97,822,322 | G/T | — | uncertain significance |
| rs2535094645 | 7:97,822,434 | C/T | — | uncertain significance |
| rs201001770 | 7:97,822,469 | G/A | — | likely benign |
| rs1034626881 | 7:97,822,478 | T/C | — | uncertain significance |
| rs116651302 | 7:97,822,506 | G/T | — | benign |
| rs1410104457 | 7:97,822,508 | A/G | — | uncertain significance |
| rs201661777 | 7:97,822,557 | A/G | — | uncertain significance |
| rs199639482 | 7:97,822,603 | A/C | — | uncertain significance |
| rs574825961 | 7:97,822,790 | G/A | — | uncertain significance |
| rs146056893 | 7:97,822,801 | G/A | — | benign |
| rs58147304 | 7:97,822,873 | C/T | — | benign |
| rs202014729 | 7:97,822,953 | C/T | — | uncertain significance |
| rs769396669 | 7:97,822,977 | T/C | — | uncertain significance |
| rs1462766724 | 7:97,822,983 | C/T | — | uncertain significance |
| rs201560033 | 7:97,823,004 | C/T | — | uncertain significance |
| rs767386758 | 7:97,823,015 | G/A | — | uncertain significance |
| rs143954866 | 7:97,823,089 | G/A | — | benign |
| rs61734171 | 7:97,823,116 | C/T | — | benign |
| rs373999502 | 7:97,823,241 | C/T | — | uncertain significance |
| rs774435216 | 7:97,823,283 | A/G | — | uncertain significance |
| rs762864662 | 7:97,823,372 | A/T | — | uncertain significance |
| rs201594580 | 7:97,823,414 | G/A | — | uncertain significance |
| rs200864795 | 7:97,823,423 | G/A | — | uncertain significance |
| rs148946045 | 7:97,823,460 | C/T | — | uncertain significance |
| rs544949950 | 7:97,823,495 | A/C | — | uncertain significance |
| rs752404533 | 7:97,823,502 | C/T | — | uncertain significance |
| rs757160740 | 7:97,823,510 | A/G | — | uncertain significance |
| rs141635153 | 7:97,823,554 | G/A | — | likely benign |
| rs761362123 | 7:97,823,618 | G/A | — | uncertain significance |
| rs200822417 | 7:97,823,675 | G/A | — | uncertain significance |
| rs767307964 | 7:97,823,769 | G/A | — | uncertain significance |
| rs765280774 | 7:97,823,790 | C/T | — | uncertain significance |
| rs150067560 | 7:97,823,816 | G/A | — | uncertain significance |
| rs2535099464 | 7:97,823,864 | A/G | — | uncertain significance |
| rs11764933 | 7:97,825,188 | G/T | — | — |
| rs1495525 | 7:97,826,232 | G/A | intron variant | — |
| rs1046095421 | 7:97,832,892 | C/G | — | uncertain significance |
| rs116216163 | 7:97,832,927 | G/C | — | benign |
| rs376374002 | 7:97,832,931 | G/A | — | uncertain significance |
| rs753044039 | 7:97,832,946 | G/A | — | likely benign |
| rs1797742295 | 7:97,832,965 | G/T | — | uncertain significance |
| rs778384389 | 7:97,832,970 | C/T | — | uncertain significance |
| rs757663394 | 7:97,833,007 | C/T | — | uncertain significance |
| rs774314131 | 7:97,833,324 | C/T | — | uncertain significance |
| rs773228939 | 7:97,833,388 | C/T | — | uncertain significance |
| rs141683058 | 7:97,833,403 | C/T | — | uncertain significance |
| rs145344475 | 7:97,833,424 | G/A | — | uncertain significance |
| rs1244106296 | 7:97,833,436 | C/G | — | uncertain significance |
| rs58880085 | 7:97,836,465 | T/C | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.