LNX1
ligand of numb-protein X 1
Summary
This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]
Known Variants57 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs771016443 | 4:54,327,103 | T/A | — | uncertain significance |
| rs776879628 | 4:54,327,112 | T/A | — | uncertain significance |
| rs761777197 | 4:54,327,160 | T/G | — | uncertain significance |
| rs545650658 | 4:54,327,689 | C/T | — | uncertain significance |
| rs750764291 | 4:54,327,737 | A/G | — | uncertain significance |
| rs2412488 | 4:54,330,867 | A/T | — | — |
| rs59651495 | 4:54,337,311 | T/C | intron variant | — |
| rs12503229 | 4:54,338,855 | A/G | — | — |
| rs62323564 | 4:54,340,999 | T/C | intron variant | — |
| rs747755451 | 4:54,343,025 | T/C | — | uncertain significance |
| rs760001997 | 4:54,343,047 | C/T | — | uncertain significance |
| rs370457052 | 4:54,343,100 | C/T | — | uncertain significance |
| rs542542903 | 4:54,344,810 | T/C | — | uncertain significance |
| rs141236658 | 4:54,344,855 | G/A | — | uncertain significance |
| rs1161444590 | 4:54,347,936 | C/T | — | uncertain significance |
| rs138151311 | 4:54,347,946 | C/T | — | likely benign |
| rs62323567 | 4:54,349,317 | C/T | intron variant | — |
| rs56921221 | 4:54,352,164 | G/A | intron variant | — |
| rs12642437 | 4:54,361,792 | C/T | upstream gene variant | — |
| rs1204311242 | 4:54,362,209 | C/T | — | uncertain significance |
| rs137886645 | 4:54,362,225 | A/G | — | uncertain significance |
| rs112295046 | 4:54,362,332 | T/C | — | uncertain significance |
| rs374285786 | 4:54,362,345 | G/A | — | uncertain significance |
| rs2476502450 | 4:54,362,354 | T/C | — | uncertain significance |
| rs2476502512 | 4:54,362,374 | G/A | — | uncertain significance |
| rs142320407 | 4:54,362,413 | C/T | — | uncertain significance |
| rs778584257 | 4:54,362,422 | T/C | — | uncertain significance |
| rs2476502670 | 4:54,362,423 | A/C | — | uncertain significance |
| rs551214184 | 4:54,362,471 | G/A | — | uncertain significance |
| rs1725260358 | 4:54,364,945 | C/G | — | uncertain significance |
| rs1425394112 | 4:54,364,950 | C/T | — | uncertain significance |
| rs1725965903 | 4:54,373,486 | T/C | — | uncertain significance |
| rs143497847 | 4:54,373,551 | G/C | — | uncertain significance |
| rs763347762 | 4:54,373,586 | T/A | — | uncertain significance |
| rs141603317 | 4:54,373,613 | T/C | — | uncertain significance |
| rs576351722 | 4:54,373,622 | T/C | — | uncertain significance |
| rs199823248 | 4:54,373,634 | G/A | — | uncertain significance |
| rs757156927 | 4:54,374,249 | C/T | — | uncertain significance |
| rs12501431 | 4:54,376,220 | T/G | intron variant | — |
| rs62323601 | 4:54,377,991 | C/A | intron variant | — |
| rs1435218 | 4:54,401,899 | C/T | intron variant | association |
| rs112575086 | 4:54,429,890 | C/A | — | — |
| rs572694542 | 4:54,439,870 | C/G | — | uncertain significance |
| rs760126360 | 4:54,439,889 | A/T | — | uncertain significance |
| rs766883204 | 4:54,439,890 | C/A | — | uncertain significance |
| rs371167938 | 4:54,439,895 | A/T | — | uncertain significance |
| rs778093950 | 4:54,439,934 | C/T | — | uncertain significance |
| rs746336204 | 4:54,440,006 | G/A | — | uncertain significance |
| rs753026832 | 4:54,440,036 | A/G | — | uncertain significance |
| rs781109488 | 4:54,440,060 | T/C | — | uncertain significance |
| rs199747919 | 4:54,440,133 | G/C | — | uncertain significance |
| rs568710395 | 4:54,480,595 | C/G | — | — |
| rs2616418 | 4:54,490,487 | G/A | intron variant | — |
| rs62325510 | 4:54,506,784 | C/G | regulatory region variant | — |
| rs17730883 | 4:54,511,847 | G/C | intron variant | — |
| rs4864809 | 4:54,511,913 | G/A | intron variant | — |
| rs6843291 | 4:54,518,222 | G/A | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.