LPAR1
lysophosphatidic acid receptor 1
Summary
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs527765818 | 9:113,637,765 | G/A | — | uncertain significance |
| rs142117056 | 9:113,637,790 | C/T | — | uncertain significance |
| rs200850518 | 9:113,637,882 | G/A | — | uncertain significance |
| rs373021969 | 9:113,637,951 | A/G | — | uncertain significance |
| rs491855 | 9:113,638,739 | T/C | intron variant | — |
| rs547116 | 9:113,640,132 | T/A | intron variant | — |
| rs1751242 | 9:113,641,783 | T/C | — | — |
| rs573900 | 9:113,642,363 | C/G | — | — |
| rs10980623 | 9:113,660,537 | A/G | intron variant | — |
| rs10980624 | 9:113,661,528 | C/T | — | — |
| rs4978966 | 9:113,662,374 | C/G | — | — |
| rs1007000 | 9:113,662,681 | C/T | upstream gene variant | — |
| rs10980628 | 9:113,671,403 | T/C | intron variant | — |
| rs72748148 | 9:113,677,241 | G/A | intron variant | — |
| rs772630337 | 9:113,703,713 | C/T | — | uncertain significance |
| rs2538550540 | 9:113,703,763 | G/A | — | uncertain significance |
| rs2538550678 | 9:113,703,764 | A/T | — | uncertain significance |
| rs2538563289 | 9:113,703,985 | A/G | — | uncertain significance |
| rs770286316 | 9:113,704,040 | G/A | — | likely benign |
| rs41279057 | 9:113,704,059 | C/T | — | benign |
| rs2538576455 | 9:113,704,177 | A/G | — | uncertain significance |
| rs973550044 | 9:113,704,253 | G/A | — | uncertain significance |
| rs370198772 | 9:113,704,262 | G/A | — | uncertain significance |
| rs147151638 | 9:113,704,313 | T/C | — | uncertain significance |
| rs757912248 | 9:113,704,435 | T/C | — | uncertain significance |
| rs12552348 | 9:113,705,204 | A/T | regulatory region variant | — |
| rs2539945360 | 9:113,734,385 | A/G | — | uncertain significance |
| rs4978978 | 9:113,802,433 | C/A | — | — |
| rs10980705 | 9:113,803,185 | C/T | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.