LRRFIP2
LRR binding FLII interacting protein 2
Summary
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs10849 | 3:37,095,070 | C/T | downstream gene variant | benign |
| rs768362515 | 3:37,095,347 | G/C | — | uncertain significance |
| rs201785920 | 3:37,095,391 | C/T | — | uncertain significance |
| rs376522215 | 3:37,095,999 | C/T | — | uncertain significance |
| rs1051838376 | 3:37,096,597 | T/C | — | uncertain significance |
| rs2110194 | 3:37,097,087 | C/T | downstream gene variant | — |
| rs2471804547 | 3:37,100,351 | C/A | — | uncertain significance |
| rs762677172 | 3:37,100,352 | C/T | — | uncertain significance |
| rs58970254 | 3:37,100,359 | A/C | — | benign |
| rs139151890 | 3:37,100,367 | C/T | — | uncertain significance |
| rs1468713 | 3:37,106,115 | A/G | intron variant | — |
| rs983341461 | 3:37,107,357 | G/C | — | uncertain significance |
| rs373309350 | 3:37,107,396 | T/C | — | uncertain significance |
| rs374682676 | 3:37,107,797 | T/C | — | uncertain significance |
| rs6550448 | 3:37,108,896 | T/A | downstream gene variant | — |
| rs148648107 | 3:37,118,345 | G/A | intron variant | — |
| rs776007946 | 3:37,132,996 | C/T | — | uncertain significance |
| rs532455806 | 3:37,132,999 | C/T | — | uncertain significance |
| rs146375765 | 3:37,136,284 | C/T | — | uncertain significance |
| rs753205411 | 3:37,138,112 | T/G | — | uncertain significance |
| rs75968372 | 3:37,144,422 | A/G | — | benign |
| rs765676498 | 3:37,144,492 | C/A | — | uncertain significance |
| rs957662754 | 3:37,146,959 | C/T | — | likely benign |
| rs926429001 | 3:37,146,980 | G/C | — | uncertain significance |
| rs368205831 | 3:37,149,566 | C/T | — | uncertain significance |
| rs1223979576 | 3:37,149,577 | C/T | — | uncertain significance |
| rs758412191 | 3:37,149,581 | C/A | — | uncertain significance |
| rs144997018 | 3:37,150,162 | T/C | — | likely benign |
| rs773335626 | 3:37,151,161 | T/C | — | uncertain significance |
| rs762611510 | 3:37,152,542 | A/C | — | uncertain significance |
| rs1378275729 | 3:37,154,437 | T/G | — | uncertain significance |
| rs2094604606 | 3:37,154,452 | G/C | — | uncertain significance |
| rs1300451870 | 3:37,162,994 | C/G | — | uncertain significance |
| rs750335262 | 3:37,163,137 | G/A | — | uncertain significance |
| rs1559940802 | 3:37,163,148 | G/A | — | uncertain significance |
| rs139582627 | 3:37,163,155 | G/A | — | uncertain significance |
| rs199604771 | 3:37,163,175 | G/A | — | uncertain significance |
| rs779235952 | 3:37,169,134 | A/G | — | uncertain significance |
| rs2474984017 | 3:37,169,153 | C/G | — | uncertain significance |
| rs2474984176 | 3:37,169,154 | A/C | — | uncertain significance |
| rs386352387 | 3:37,190,384 | C/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.