LRRTM4

leucine rich repeat transmembrane neuronal 4

Summary

Predicted to enable heparan sulfate proteoglycan binding activity. Predicted to be involved in regulation of synapse assembly. Predicted to act upstream of or within AMPA glutamate receptor clustering; positive regulation of synapse assembly; and regulation of presynaptic membrane organization. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in several cellular components, including GABA-ergic synapse; photoreceptor ribbon synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants43 total

rsidPosition (GRCh37)AllelesClassClinVar
rs16727368412:76,975,867G/Auncertain significance
rs5385222282:76,975,900A/Cuncertain significance
rs2003283272:76,975,931G/Cuncertain significance
rs1912642642:77,134,793A/Tintron variant
rs21785742:77,152,610A/Gintron variant
rs48532832:77,156,402A/Gintron variant
rs14705062:77,223,938C/Tintron variant
rs559853032:77,224,951G/Aintron variant
rs14467022:77,235,470A/Tintron variant
rs65471152:77,246,331A/T
rs728072032:77,292,600C/Tintron variant
rs1481024082:77,318,982A/C
rs1387999552:77,319,073A/T
rs621687662:77,332,735C/G
rs584494642:77,334,916T/Cintron variant
rs728091292:77,475,663C/Aintron variant
rs58322762:77,582,084A/G
rs1855255722:77,638,066A/Gintron variant
rs116799432:77,724,624G/Aintron variant
rs67618382:77,730,997A/Tintron variant
rs14808322532:77,745,506C/Tuncertain significance
rs7517432142:77,745,551G/Tuncertain significance
rs3762464572:77,745,626G/Cuncertain significance
rs7656819742:77,745,661A/Guncertain significance
rs9410942252:77,745,664T/Cuncertain significance
rs3711913952:77,745,782A/Tuncertain significance
rs7701285882:77,745,875C/Guncertain significance
rs16793479602:77,745,953C/Tuncertain significance
rs3677420602:77,745,962T/Cuncertain significance
rs7651450082:77,746,123T/Cuncertain significance
rs24661029932:77,746,148T/Cuncertain significance
rs24661037562:77,746,225T/Cuncertain significance
rs12469900762:77,746,245C/Auncertain significance
rs5655538552:77,746,475T/Cuncertain significance
rs24661060362:77,746,578G/Tuncertain significance
rs24661060482:77,746,579T/Guncertain significance
rs7616255282:77,746,619T/Cuncertain significance
rs7575830212:77,746,701G/Alikely benign
rs763275762:77,746,839G/Clikely benign
rs24661082972:77,746,910C/Tuncertain significance
rs3773713742:77,746,957C/Tuncertain significance
rs14254304432:77,746,961T/Cuncertain significance
rs3742449062:77,748,834C/Aregulatory region variant

Gene information from NCBI Gene. Variant classifications from ClinVar.