MRC1
mannose receptor C-type 1
Summary
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
Known Variants23 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs200265081 | 10:17,855,003 | G/A | — | — |
| rs2253120 | 10:17,865,254 | G/A | synonymous variant | — |
| rs4748422 | 10:17,872,653 | G/C | — | — |
| rs782152231 | 10:17,875,780 | A/G | — | likely benign |
| rs2477664 | 10:17,875,816 | T/A | synonymous variant | — |
| rs35160301 | 10:17,877,539 | C/A | intron variant | — |
| rs692527 | 10:18,129,993 | G/A | — | — |
| rs373423276 | 10:18,130,016 | T/C | — | — |
| rs527925 | 10:18,132,562 | T/A | — | — |
| rs4748424 | 10:18,135,613 | A/G | downstream gene variant | — |
| rs200793564 | 10:18,135,686 | T/C | — | — |
| rs368174648 | 10:18,135,953 | T/C | — | — |
| rs12359178 | 10:18,136,543 | G/A | downstream gene variant | — |
| rs782295458 | 10:18,138,554 | C/T | — | likely benign |
| rs606231248 | 10:18,138,630 | G/A | — | risk factor |
| rs926148465 | 10:18,140,129 | A/G | — | — |
| rs548129723 | 10:18,154,100 | G/T | — | — |
| rs690753 | 10:18,155,285 | A/C | — | — |
| rs141126876 | 10:18,155,494 | G/A | missense variant | — |
| rs61844058 | 10:18,156,314 | T/A | — | — |
| rs915276099 | 10:18,167,723 | C/T | — | — |
| rs200928899 | 10:18,176,468 | T/C | — | — |
| rs543741131 | 10:18,183,335 | T/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.