MSMB
microseminoprotein beta
Summary
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Known Variants8 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12770171 | 10:51,549,314 | C/T | upstream gene variant | — |
| rs141211965 | 10:51,549,473 | C/T | upstream gene variant | — |
| rs10993994 | 10:51,549,496 | T/C | upstream gene variant | risk factor |
| rs41274660 | 10:51,549,533 | T/G | 5 prime UTR variant | — |
| rs200303971 | 10:51,555,807 | A/G | — | uncertain significance |
| rs7904463 | 10:51,559,469 | C/A | — | — |
| rs2496545257 | 10:51,562,282 | C/T | — | uncertain significance |
| rs1392919719 | 10:51,562,351 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.