MTF1
metal regulatory transcription factor 1
Summary
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs28411352 | 1:38,278,579 | C/T | upstream gene variant | — |
| rs3748682 | 1:38,279,987 | T/C | downstream gene variant | — |
| rs201554271 | 1:38,280,848 | C/A | — | uncertain significance |
| rs201482284 | 1:38,280,866 | A/G | — | uncertain significance |
| rs116143945 | 1:38,280,907 | T/C | — | likely benign |
| rs778161562 | 1:38,280,974 | C/T | — | uncertain significance |
| rs759516756 | 1:38,281,007 | G/A | — | uncertain significance |
| rs538283687 | 1:38,281,017 | C/T | — | uncertain significance |
| rs974664771 | 1:38,281,037 | A/G | — | uncertain significance |
| rs138397545 | 1:38,281,046 | G/T | — | uncertain significance |
| rs534357571 | 1:38,281,098 | G/C | — | uncertain significance |
| rs1429793686 | 1:38,287,917 | G/C | — | uncertain significance |
| rs778733995 | 1:38,287,987 | T/C | — | uncertain significance |
| rs140161506 | 1:38,287,992 | T/G | — | uncertain significance |
| rs2524574883 | 1:38,288,035 | C/T | — | uncertain significance |
| rs746233691 | 1:38,288,085 | G/A | — | uncertain significance |
| rs1239183699 | 1:38,288,089 | C/T | — | uncertain significance |
| rs142864227 | 1:38,288,100 | G/A | — | uncertain significance |
| rs9729276 | 1:38,288,227 | G/A | — | likely benign |
| rs375968162 | 1:38,288,233 | G/A | — | uncertain significance |
| rs61734999 | 1:38,288,242 | G/A | — | benign |
| rs914268855 | 1:38,288,272 | G/T | — | uncertain significance |
| rs1366179494 | 1:38,288,309 | T/G | — | uncertain significance |
| rs1363613252 | 1:38,288,314 | A/G | — | uncertain significance |
| rs140764958 | 1:38,288,336 | C/T | — | likely benign |
| rs79630033 | 1:38,289,462 | G/A | — | likely benign |
| rs777032664 | 1:38,297,922 | T/C | — | uncertain significance |
| rs1412592051 | 1:38,297,934 | G/A | — | uncertain significance |
| rs9729719 | 1:38,298,207 | G/A | upstream gene variant | — |
| rs3891572 | 1:38,298,876 | C/T | upstream gene variant | — |
| rs1250493612 | 1:38,300,779 | T/C | — | likely benign |
| rs1269651707 | 1:38,301,412 | C/T | — | uncertain significance |
| rs373276636 | 1:38,304,392 | C/T | — | likely benign |
| rs2524635251 | 1:38,305,619 | C/A | — | uncertain significance |
| rs61778082 | 1:38,306,356 | T/C | upstream gene variant | — |
| rs1000640324 | 1:38,323,080 | A/G | — | uncertain significance |
| rs2524687217 | 1:38,323,081 | T/C | — | uncertain significance |
| rs1232226927 | 1:38,323,087 | G/A | — | uncertain significance |
| rs552143498 | 1:38,323,127 | T/G | — | benign |
| rs41267341 | 1:38,323,142 | G/T | — | benign |
| rs1296774230 | 1:38,323,161 | G/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.