NCOR2

nuclear receptor corepressor 2

Summary

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

Known Variants326 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs8546	12:124,809,027	G/A	regulatory region variant	—
rs2547378033	12:124,809,956	T/A	—	uncertain significance
rs897710434	12:124,809,959	C/A	—	uncertain significance
rs2547378057	12:124,809,965	G/C	—	uncertain significance
rs2034542280	12:124,809,967	G/C	—	uncertain significance
rs1593051320	12:124,809,973	T/G	—	uncertain significance
rs2034542765	12:124,809,976	T/A	—	uncertain significance
rs1007255615	12:124,809,977	G/T	—	uncertain significance
rs2034543440	12:124,809,992	G/A	—	uncertain significance
rs985828412	12:124,810,010	A/G	—	uncertain significance
rs1402295087	12:124,810,016	G/A	—	uncertain significance
rs77107801	12:124,810,028	C/T	—	benign
rs1488001578	12:124,810,045	G/A	—	uncertain significance
rs745312035	12:124,810,046	C/T	—	uncertain significance
rs749208308	12:124,810,060	G/A	—	uncertain significance
rs772122155	12:124,810,083	C/T	—	likely benign
rs200312114	12:124,810,093	C/T	—	uncertain significance
rs189013704	12:124,810,134	G/A	—	likely benign
rs11057583	12:124,810,329	G/A	intron variant	—
rs199646358	12:124,810,741	G/A	—	likely benign
rs751919228	12:124,810,766	C/T	—	uncertain significance
rs760358213	12:124,810,767	G/A	—	uncertain significance
rs187350105	12:124,810,804	C/T	—	benign
rs61744311	12:124,810,837	C/A	—	benign
rs758304924	12:124,810,868	G/A	—	uncertain significance
rs199762590	12:124,810,911	C/T	—	uncertain significance
rs749361594	12:124,810,912	G/A	—	likely benign
rs201513599	12:124,811,994	C/T	—	uncertain significance
rs199616664	12:124,812,062	G/A	—	uncertain significance
rs770920489	12:124,812,069	A/T	—	uncertain significance
rs2547385233	12:124,812,134	G/C	—	uncertain significance
rs370064389	12:124,812,167	T/C	—	likely benign
rs2547402175	12:124,817,005	C/T	—	uncertain significance
rs188154393	12:124,817,711	C/T	—	likely benign
rs201904368	12:124,817,719	C/T	—	likely benign
rs199593681	12:124,817,732	G/A	—	likely benign
rs75362677	12:124,817,756	C/T	—	likely benign
rs750252948	12:124,817,767	C/A	—	uncertain significance
rs1472840	12:124,817,806	T/G	—	benign
rs369612880	12:124,818,975	G/C	—	likely benign
rs181072341	12:124,818,984	G/A	—	benign
rs377045126	12:124,818,994	G/T	—	uncertain significance
rs201853086	12:124,819,002	G/C	—	likely benign
rs758038755	12:124,819,027	G/A	—	uncertain significance
rs774421685	12:124,819,054	C/T	—	uncertain significance
rs761892157	12:124,819,055	G/A	—	uncertain significance
rs749041664	12:124,819,116	G/A	—	likely benign
rs376757891	12:124,819,673	G/A	—	likely benign
rs893086396	12:124,819,746	G/T	—	uncertain significance
rs35980493	12:124,819,747	C/T	—	benign
rs199899276	12:124,819,748	G/A	—	uncertain significance
rs1291081651	12:124,819,772	G/A	—	uncertain significance
rs147020677	12:124,819,800	C/T	—	uncertain significance
rs1106317	12:124,820,013	A/G	—	benign
rs201766557	12:124,820,043	C/T	—	uncertain significance
rs1258251678	12:124,820,059	G/C	—	uncertain significance
rs775031589	12:124,820,104	C/T	—	uncertain significance
rs116511777	12:124,820,138	G/A	—	benign
rs766514734	12:124,820,157	C/G	—	uncertain significance
rs1250257132	12:124,821,367	G/A	—	uncertain significance
rs762352790	12:124,821,373	G/A	—	likely benign
rs371641181	12:124,821,384	C/T	—	likely benign
rs756304172	12:124,821,391	G/A	—	uncertain significance
rs768697193	12:124,821,397	G/A	—	uncertain significance
rs115287138	12:124,821,403	G/A	—	benign
rs2230944	12:124,821,413	A/G	—	benign
rs2227277	12:124,821,416	C/T	—	benign
rs367841669	12:124,821,430	G/T	—	uncertain significance
rs371285197	12:124,821,436	C/T	—	uncertain significance
rs368518568	12:124,821,440	C/T	—	uncertain significance
rs372512195	12:124,821,449	C/T	—	uncertain significance
rs2230943	12:124,821,483	C/A	—	benign
rs753634167	12:124,821,486	C/T	—	likely benign
rs1593107841	12:124,821,505	G/T	—	likely pathogenic
rs376833353	12:124,821,522	G/A	—	likely benign
rs757650627	12:124,821,568	C/T	—	uncertain significance
rs932680959	12:124,821,574	C/T	—	uncertain significance
rs776517719	12:124,821,593	G/A	—	uncertain significance
rs199729163	12:124,821,618	G/A	—	benign
rs1386301961	12:124,821,655	C/T	—	uncertain significance
rs192319351	12:124,821,656	C/T	—	likely benign
rs1392424266	12:124,821,662	G/C	—	uncertain significance
rs61751354	12:124,821,666	G/A	—	benign
rs2229842	12:124,821,696	C/T	—	benign
rs375846724	12:124,821,704	C/T	—	uncertain significance
rs3741512	12:124,821,705	G/A	—	benign
rs376844948	12:124,824,583	C/T	—	uncertain significance
rs367866393	12:124,824,585	G/T	—	uncertain significance
rs202106373	12:124,824,613	G/A	—	uncertain significance
rs369062283	12:124,824,641	A/T	—	uncertain significance
rs764396899	12:124,824,690	G/C	—	uncertain significance
rs200488675	12:124,824,694	C/A	—	uncertain significance
rs577745902	12:124,824,703	T/C	—	uncertain significance
rs2547433282	12:124,824,873	T/C	—	uncertain significance
rs375229118	12:124,824,906	G/A	—	uncertain significance
rs754008044	12:124,824,912	G/A	—	uncertain significance
rs747685237	12:124,824,949	C/T	—	likely benign
rs774775666	12:124,825,174	C/T	—	uncertain significance
rs12422607	12:124,825,175	G/A	—	uncertain significance
rs1185827840	12:124,825,229	T/A	—	uncertain significance

Showing 100 of 326 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.