OPCML
opioid binding protein/cell adhesion molecule like
Summary
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Known Variants33 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs771254331 | 11:132,290,107 | G/A | — | uncertain significance |
| rs2499343468 | 11:132,290,111 | T/A | — | likely benign |
| rs113899050 | 11:132,305,043 | C/T | — | benign |
| rs377189862 | 11:132,306,021 | G/T | — | uncertain significance |
| rs770267945 | 11:132,306,024 | G/A | — | uncertain significance |
| rs199807233 | 11:132,306,107 | C/T | — | uncertain significance |
| rs755175009 | 11:132,306,586 | A/G | — | uncertain significance |
| rs1255856941 | 11:132,307,199 | C/T | — | uncertain significance |
| rs2499476149 | 11:132,307,200 | G/C | — | uncertain significance |
| rs563954 | 11:132,391,656 | A/G | upstream gene variant | — |
| rs145182728 | 11:132,399,001 | A/G | — | likely benign |
| rs1046287812 | 11:132,399,062 | T/G | — | uncertain significance |
| rs1784519 | 11:132,526,865 | A/C | — | — |
| rs548104590 | 11:132,527,007 | C/T | — | likely benign |
| rs137852691 | 11:132,527,098 | G/C | missense variant | pathogenic |
| rs2501217692 | 11:132,527,144 | C/T | — | uncertain significance |
| rs201425009 | 11:132,527,197 | C/T | — | uncertain significance |
| rs2917570 | 11:132,569,761 | T/G | intron variant | — |
| rs3016384 | 11:132,573,390 | C/T | intron variant | — |
| rs1793257 | 11:132,584,119 | C/T | intron variant | — |
| rs7924465 | 11:132,636,983 | T/C | intron variant | — |
| rs2007518 | 11:132,639,606 | A/G | intron variant | — |
| rs10894604 | 11:132,641,746 | T/G | intron variant | — |
| rs34814382 | 11:132,701,183 | C/G | — | — |
| rs550829245 | 11:132,701,325 | C/T | — | — |
| rs7938407 | 11:132,702,488 | C/T | intron variant | — |
| rs1416404567 | 11:132,812,912 | G/A | — | uncertain significance |
| rs1567127 | 11:132,829,862 | A/C | — | — |
| rs7107209 | 11:133,118,889 | A/C | — | — |
| rs2078454 | 11:133,120,937 | C/G | — | — |
| rs4379857 | 11:133,183,604 | G/A | intron variant | — |
| rs11223444 | 11:133,221,928 | A/C | — | — |
| rs7117082 | 11:133,392,294 | G/T | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.