PARP10
poly(ADP-ribose) polymerase family member 10
Summary
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Known Variants83 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2540082203 | 8:145,051,657 | T/A | — | uncertain significance |
| rs782782139 | 8:145,051,684 | A/T | — | uncertain significance |
| rs200484193 | 8:145,051,717 | C/T | — | likely benign |
| rs781931485 | 8:145,051,768 | A/C | — | uncertain significance |
| rs782340559 | 8:145,051,777 | G/T | — | uncertain significance |
| rs928092024 | 8:145,051,790 | G/T | — | uncertain significance |
| rs939598803 | 8:145,051,791 | T/C | — | uncertain significance |
| rs1323249653 | 8:145,051,797 | G/A | — | uncertain significance |
| rs1833724472 | 8:145,051,804 | C/G | — | uncertain significance |
| rs144692936 | 8:145,051,905 | G/A | — | uncertain significance |
| rs201895679 | 8:145,051,926 | G/C | — | uncertain significance |
| rs2540084394 | 8:145,051,950 | G/A | — | uncertain significance |
| rs2540085660 | 8:145,052,087 | A/T | — | uncertain significance |
| rs782698203 | 8:145,052,137 | G/A | — | uncertain significance |
| rs2540086589 | 8:145,052,222 | G/C | — | uncertain significance |
| rs782059692 | 8:145,052,227 | A/G | — | uncertain significance |
| rs62530285 | 8:145,054,271 | T/A | — | — |
| rs141811386 | 8:145,057,106 | G/A | — | likely benign |
| rs371846207 | 8:145,057,152 | C/T | — | likely benign |
| rs782062716 | 8:145,057,153 | G/A | — | uncertain significance |
| rs139271648 | 8:145,057,169 | C/G | — | conflicting classifications of pathogenicity |
| rs1165218880 | 8:145,057,173 | C/T | — | uncertain significance |
| rs2540102019 | 8:145,057,195 | C/T | — | uncertain significance |
| rs1554748090 | 8:145,057,213 | C/T | — | uncertain significance |
| rs147273541 | 8:145,057,221 | G/A | — | uncertain significance |
| rs2540102680 | 8:145,057,364 | G/A | — | uncertain significance |
| rs144813673 | 8:145,057,409 | C/T | — | uncertain significance |
| rs782311642 | 8:145,057,491 | G/A | — | uncertain significance |
| rs142994580 | 8:145,057,499 | C/T | — | uncertain significance |
| rs200251958 | 8:145,057,505 | C/T | — | conflicting classifications of pathogenicity |
| rs199825165 | 8:145,057,530 | G/T | — | uncertain significance |
| rs782806863 | 8:145,057,586 | C/T | — | likely benign |
| rs782420418 | 8:145,057,655 | C/T | — | uncertain significance |
| rs200427491 | 8:145,057,656 | C/A | — | uncertain significance |
| rs1554748275 | 8:145,057,686 | G/C | — | uncertain significance |
| rs782279171 | 8:145,057,718 | C/T | — | likely benign |
| rs555688006 | 8:145,057,772 | C/T | — | uncertain significance |
| rs372169959 | 8:145,057,773 | G/A | — | uncertain significance |
| rs377032580 | 8:145,057,785 | G/C | — | uncertain significance |
| rs143844399 | 8:145,057,817 | G/A | — | uncertain significance |
| rs782760652 | 8:145,057,932 | C/T | — | uncertain significance |
| rs1303214858 | 8:145,058,210 | G/C | — | uncertain significance |
| rs781816139 | 8:145,058,217 | G/T | — | uncertain significance |
| rs200821571 | 8:145,058,245 | G/A | — | uncertain significance |
| rs199641585 | 8:145,058,272 | C/T | — | uncertain significance |
| rs74677817 | 8:145,058,398 | A/C | — | uncertain significance |
| rs868908655 | 8:145,058,497 | C/T | — | uncertain significance |
| rs782049000 | 8:145,058,533 | T/C | — | uncertain significance |
| rs755624307 | 8:145,058,553 | C/T | — | likely benign |
| rs781795471 | 8:145,058,584 | C/T | — | likely benign |
| rs782238694 | 8:145,058,714 | G/A | — | uncertain significance |
| rs782360810 | 8:145,058,731 | G/A | — | uncertain significance |
| rs2540108026 | 8:145,058,852 | G/C | — | uncertain significance |
| rs2540108270 | 8:145,058,940 | T/G | — | uncertain significance |
| rs144746265 | 8:145,059,026 | C/T | — | uncertain significance |
| rs201415412 | 8:145,059,215 | T/A | — | uncertain significance |
| rs782128523 | 8:145,059,226 | T/G | — | uncertain significance |
| rs2540109778 | 8:145,059,332 | T/C | — | likely benign |
| rs782403822 | 8:145,059,341 | G/A | — | uncertain significance |
| rs782348319 | 8:145,059,352 | G/A | — | uncertain significance |
| rs76489217 | 8:145,059,438 | G/A | — | benign |
| rs781891828 | 8:145,059,606 | G/A | — | uncertain significance |
| rs141423961 | 8:145,059,664 | G/A | — | likely benign |
| rs2540111187 | 8:145,059,666 | T/C | — | uncertain significance |
| rs1299345904 | 8:145,059,727 | G/A | — | uncertain significance |
| rs374968175 | 8:145,059,750 | C/T | — | uncertain significance |
| rs146902781 | 8:145,059,781 | C/T | — | likely benign |
| rs782137513 | 8:145,059,786 | T/A | — | uncertain significance |
| rs1032718340 | 8:145,059,808 | C/T | — | uncertain significance |
| rs1833974239 | 8:145,059,922 | G/C | — | uncertain significance |
| rs782108852 | 8:145,059,928 | G/A | — | uncertain significance |
| rs782809943 | 8:145,059,936 | C/T | — | uncertain significance |
| rs199585712 | 8:145,059,937 | G/A | — | uncertain significance |
| rs1021037901 | 8:145,060,057 | G/A | — | uncertain significance |
| rs541952106 | 8:145,060,068 | C/T | — | uncertain significance |
| rs782116732 | 8:145,060,247 | C/T | — | likely benign |
| rs782082984 | 8:145,060,298 | G/A | — | uncertain significance |
| rs200680602 | 8:145,060,303 | C/A | — | uncertain significance |
| rs782179876 | 8:145,060,390 | G/A | — | uncertain significance |
| rs58404036 | 8:145,069,534 | C/T | downstream gene variant | — |
| rs56207135 | 8:145,070,567 | G/C | regulatory region variant | — |
| rs57957974 | 8:145,076,529 | C/A | intron variant | — |
| rs60050811 | 8:145,086,876 | T/C | missense variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.