PATJ

PATJ crumbs cell polarity complex component

Summary

This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]

Known Variants41 total

rsidPosition (GRCh37)AllelesClassClinVar
rs25237068771:62,232,136G/Tuncertain significance
rs25237783531:62,234,970T/Cuncertain significance
rs3695748821:62,239,319C/T
rs793882261:62,241,015A/Gbenign
rs748910191:62,245,463T/Cintron variant
rs1422736801:62,253,583C/Alikely benign
rs1152416831:62,253,601T/Cbenign
rs3758614941:62,267,297A/Guncertain significance
rs1502914941:62,267,321C/Tmissense variant
rs3746680021:62,267,391A/Guncertain significance
rs5566135421:62,293,125G/Tuncertain significance
rs3763867951:62,293,184C/Tuncertain significance
rs412894221:62,321,734G/Tlikely benign
rs1389094201:62,321,759G/Auncertain significance
rs1165442671:62,327,304G/Cbenign
rs1125484431:62,329,993A/Gbenign
rs49157871:62,330,134G/Abenign
rs3713330951:62,341,024C/Glikely benign
rs25264285061:62,349,926G/Auncertain significance
rs1168440481:62,365,321G/Alikely benign
rs1508361591:62,374,104G/Tuncertain significance
rs1998886201:62,380,262A/Guncertain significance
rs10565131:62,380,298G/Cmissense variant
rs1436430541:62,393,426A/Guncertain significance
rs10271192841:62,483,535A/Guncertain significance
rs2016090331:62,483,560C/Guncertain significance
rs759008251:62,483,586C/Tbenign
rs740765141:62,545,246T/Cbenign
rs10496292571:62,557,439T/A
rs1449588611:62,574,186A/Guncertain significance
rs2015145151:62,579,757C/Tlikely benign
rs1449835461:62,579,809G/Tuncertain significance
rs1899450421:62,579,834G/Auncertain significance
rs2007229451:62,582,235G/Auncertain significance
rs7757542731:62,582,250G/Auncertain significance
rs7496521821:62,593,645A/Cuncertain significance
rs2015760621:62,593,682A/Gbenign
rs1415492301:62,593,737G/Auncertain significance
rs1874172421:62,594,536T/Abenign
rs5385229681:62,597,230G/C
rs5743990461:62,607,042A/G

Gene information from NCBI Gene. Variant classifications from ClinVar.