PLA2G12B
phospholipase A2 group XIIB
Summary
The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Known Variants12 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1445846598 | 10:74,695,403 | C/T | — | uncertain significance |
| rs1239393327 | 10:74,695,452 | T/C | — | uncertain significance |
| rs1460278551 | 10:74,695,458 | C/T | — | uncertain significance |
| rs775354846 | 10:74,700,977 | G/A | — | uncertain significance |
| rs907997629 | 10:74,700,986 | C/A | — | uncertain significance |
| rs1846381108 | 10:74,702,418 | G/A | — | uncertain significance |
| rs745439702 | 10:74,702,448 | A/G | — | uncertain significance |
| rs7904738 | 10:74,710,484 | G/C | intron variant | — |
| rs780950361 | 10:74,714,361 | T/C | — | uncertain significance |
| rs749224129 | 10:74,714,372 | G/C | — | uncertain significance |
| rs768585955 | 10:74,714,376 | G/A | — | uncertain significance |
| rs7074080 | 10:74,715,971 | C/A | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.