POLI
DNA polymerase iota
Summary
The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion. [provided by RefSeq, May 2017]
Known Variants47 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs761698213 | 18:51,795,983 | G/A | — | uncertain significance |
| rs200801352 | 18:51,796,025 | T/A | — | uncertain significance |
| rs763190230 | 18:51,797,801 | T/G | — | uncertain significance |
| rs139346720 | 18:51,797,822 | A/G | — | uncertain significance |
| rs2511470122 | 18:51,797,843 | G/C | — | uncertain significance |
| rs758080830 | 18:51,800,311 | A/G | — | uncertain significance |
| rs2511475498 | 18:51,800,330 | C/G | — | uncertain significance |
| rs1039348465 | 18:51,800,365 | T/G | — | uncertain significance |
| rs765626984 | 18:51,800,416 | G/A | — | uncertain significance |
| rs2511475827 | 18:51,800,428 | C/G | — | uncertain significance |
| rs151128120 | 18:51,800,442 | A/G | — | uncertain significance |
| rs3730716 | 18:51,802,787 | T/A | — | — |
| rs2511483432 | 18:51,804,090 | A/C | — | uncertain significance |
| rs602422 | 18:51,805,130 | A/G | intron variant | — |
| rs367942007 | 18:51,807,065 | C/G | — | uncertain significance |
| rs762831996 | 18:51,807,208 | C/T | — | uncertain significance |
| rs759498532 | 18:51,807,234 | C/T | — | uncertain significance |
| rs76578033 | 18:51,807,258 | A/C | — | uncertain significance |
| rs757736389 | 18:51,809,246 | G/C | — | uncertain significance |
| rs887248370 | 18:51,810,343 | A/G | — | uncertain significance |
| rs777178383 | 18:51,813,677 | A/C | — | uncertain significance |
| rs763812308 | 18:51,813,704 | A/G | — | uncertain significance |
| rs756150056 | 18:51,813,721 | T/A | — | uncertain significance |
| rs371876172 | 18:51,813,736 | C/T | — | uncertain significance |
| rs12965763 | 18:51,816,408 | G/A | intron variant | — |
| rs556632345 | 18:51,818,232 | G/C | — | uncertain significance |
| rs761958015 | 18:51,818,260 | T/C | — | uncertain significance |
| rs200144217 | 18:51,820,030 | C/G | — | uncertain significance |
| rs779484726 | 18:51,820,136 | A/G | — | uncertain significance |
| rs778771682 | 18:51,820,157 | A/G | — | uncertain significance |
| rs2088155586 | 18:51,820,305 | C/A | — | uncertain significance |
| rs1323115199 | 18:51,820,322 | T/C | — | uncertain significance |
| rs765990972 | 18:51,820,329 | T/G | — | uncertain significance |
| rs2511374317 | 18:51,820,347 | A/G | — | uncertain significance |
| rs138562746 | 18:51,820,469 | A/G | — | uncertain significance |
| rs764946326 | 18:51,820,481 | T/C | — | likely benign |
| rs751503957 | 18:51,820,512 | G/A | — | uncertain significance |
| rs776066395 | 18:51,820,521 | A/C | — | uncertain significance |
| rs765088821 | 18:51,820,578 | C/T | — | likely benign |
| rs2511375537 | 18:51,820,614 | T/C | — | uncertain significance |
| rs2511375590 | 18:51,820,620 | C/T | — | uncertain significance |
| rs2511376074 | 18:51,820,706 | G/A | — | uncertain significance |
| rs141645046 | 18:51,820,751 | T/C | — | uncertain significance |
| rs12955457 | 18:51,830,294 | C/T | intron variant | — |
| rs563611 | 18:51,836,946 | T/A | intron variant | — |
| rs503240 | 18:51,842,604 | A/G | intron variant | — |
| rs948707 | 18:51,845,450 | T/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.