PPP2R3A
protein phosphatase 2 regulatory subunit B''alpha
Summary
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
Known Variants119 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs9827662 | 3:135,710,841 | C/A | regulatory region variant | — |
| rs1301321725 | 3:135,720,360 | T/C | — | uncertain significance |
| rs191265461 | 3:135,720,478 | G/T | — | likely benign |
| rs373873200 | 3:135,720,503 | C/G | — | uncertain significance |
| rs57374999 | 3:135,720,539 | G/A | — | benign |
| rs9814557 | 3:135,720,540 | A/G | — | benign |
| rs146617069 | 3:135,720,551 | A/G | — | likely benign |
| rs145130777 | 3:135,720,572 | G/A | — | likely benign |
| rs36020282 | 3:135,720,663 | A/G | — | likely benign |
| rs748461075 | 3:135,720,664 | C/A | — | uncertain significance |
| rs9872542 | 3:135,720,673 | T/C | — | benign |
| rs6779903 | 3:135,720,851 | G/T | — | benign |
| rs1933643622 | 3:135,720,857 | T/C | — | uncertain significance |
| rs563238134 | 3:135,720,875 | A/C | — | uncertain significance |
| rs767658507 | 3:135,720,884 | G/A | — | uncertain significance |
| rs752753037 | 3:135,720,888 | A/G | — | uncertain significance |
| rs149080732 | 3:135,720,917 | C/G | — | benign |
| rs552879077 | 3:135,720,923 | A/G | — | uncertain significance |
| rs138854105 | 3:135,720,924 | C/T | — | uncertain significance |
| rs770902830 | 3:135,720,962 | G/A | — | uncertain significance |
| rs762045451 | 3:135,721,031 | A/G | — | uncertain significance |
| rs34629706 | 3:135,721,036 | T/C | — | benign |
| rs115951794 | 3:135,721,085 | G/A | — | likely benign |
| rs1020750938 | 3:135,721,160 | T/A | — | uncertain significance |
| rs2472800505 | 3:135,721,169 | G/C | — | uncertain significance |
| rs185982797 | 3:135,721,190 | A/G | — | uncertain significance |
| rs756912790 | 3:135,721,196 | G/A | — | uncertain significance |
| rs146596318 | 3:135,721,208 | A/G | — | uncertain significance |
| rs375282717 | 3:135,721,230 | T/A | — | uncertain significance |
| rs35214119 | 3:135,721,279 | T/G | — | uncertain significance |
| rs148965190 | 3:135,721,305 | T/C | — | uncertain significance |
| rs1201171129 | 3:135,721,353 | T/A | — | uncertain significance |
| rs35988394 | 3:135,721,380 | G/C | — | uncertain significance |
| rs71336047 | 3:135,721,486 | A/C | — | likely benign |
| rs374344182 | 3:135,721,493 | C/A | — | uncertain significance |
| rs143018023 | 3:135,721,553 | A/C | — | uncertain significance |
| rs775256562 | 3:135,721,611 | A/G | — | uncertain significance |
| rs2528973846 | 3:135,721,626 | A/G | — | uncertain significance |
| rs2528974710 | 3:135,721,680 | A/G | — | uncertain significance |
| rs1461440928 | 3:135,721,699 | A/T | — | likely benign |
| rs537703209 | 3:135,721,739 | A/G | — | uncertain significance |
| rs34901937 | 3:135,721,781 | C/G | — | benign |
| rs550646830 | 3:135,721,790 | G/A | — | uncertain significance |
| rs539446446 | 3:135,721,820 | G/A | — | uncertain significance |
| rs755183479 | 3:135,721,842 | C/T | — | uncertain significance |
| rs115431753 | 3:135,721,849 | C/T | — | likely benign |
| rs201206858 | 3:135,721,850 | A/G | — | uncertain significance |
| rs202206769 | 3:135,721,903 | G/C | — | uncertain significance |
| rs1196380294 | 3:135,721,957 | T/A | — | uncertain significance |
| rs773168740 | 3:135,721,970 | A/T | — | uncertain significance |
| rs61757744 | 3:135,721,981 | T/C | — | benign |
| rs371563412 | 3:135,721,982 | G/A | — | likely benign |
| rs35923084 | 3:135,722,030 | A/G | — | benign |
| rs61756430 | 3:135,722,125 | G/A | — | benign |
| rs138504743 | 3:135,722,185 | A/G | — | likely benign |
| rs200793795 | 3:135,722,209 | A/G | — | likely benign |
| rs141649812 | 3:135,722,253 | C/T | — | benign |
| rs17197552 | 3:135,722,264 | A/G | — | benign |
| rs747152098 | 3:135,722,270 | G/A | — | uncertain significance |
| rs572779295 | 3:135,722,273 | G/T | — | uncertain significance |
| rs2528981596 | 3:135,722,313 | A/G | — | uncertain significance |
| rs367543396 | 3:135,745,716 | C/T | — | uncertain significance |
| rs756038189 | 3:135,745,744 | G/A | — | likely benign |
| rs145391296 | 3:135,745,757 | G/A | — | benign |
| rs9826032 | 3:135,745,762 | T/C | — | benign |
| rs370342610 | 3:135,745,765 | A/G | — | uncertain significance |
| rs35279847 | 3:135,745,766 | T/C | — | benign |
| rs113078246 | 3:135,745,787 | G/A | — | likely benign |
| rs35250006 | 3:135,745,810 | G/A | — | benign |
| rs1347154552 | 3:135,745,833 | C/A | — | uncertain significance |
| rs149963125 | 3:135,745,856 | A/G | — | likely benign |
| rs1934689325 | 3:135,745,885 | T/C | — | uncertain significance |
| rs747308774 | 3:135,745,891 | A/G | — | uncertain significance |
| rs16843645 | 3:135,745,911 | G/A | — | benign |
| rs141011309 | 3:135,759,743 | G/A | — | uncertain significance |
| rs905735186 | 3:135,768,160 | A/G | — | likely benign |
| rs2529158772 | 3:135,768,202 | A/G | — | uncertain significance |
| rs13082684 | 3:135,783,166 | G/A | intron variant | — |
| rs10049233 | 3:135,785,469 | G/A | intron variant | — |
| rs1936392912 | 3:135,789,323 | G/A | — | uncertain significance |
| rs753726579 | 3:135,789,360 | A/G | — | uncertain significance |
| rs2529241360 | 3:135,789,369 | A/C | — | uncertain significance |
| rs28509770 | 3:135,793,657 | C/A | — | — |
| rs147006675 | 3:135,797,206 | C/T | — | benign |
| rs61756431 | 3:135,797,232 | A/G | — | likely benign |
| rs34894639 | 3:135,798,658 | C/T | intron variant | — |
| rs34330586 | 3:135,800,409 | A/G | — | — |
| rs376444693 | 3:135,801,156 | A/C | — | uncertain significance |
| rs72985424 | 3:135,801,157 | C/T | — | benign |
| rs1463483478 | 3:135,801,159 | T/A | — | uncertain significance |
| rs764293011 | 3:135,801,239 | G/A | — | uncertain significance |
| rs377308767 | 3:135,801,249 | G/A | — | uncertain significance |
| rs1559909545 | 3:135,801,255 | A/G | — | uncertain significance |
| rs61791721 | 3:135,804,550 | T/C | — | — |
| rs756871005 | 3:135,806,772 | A/G | — | uncertain significance |
| rs371098929 | 3:135,809,421 | G/A | — | uncertain significance |
| rs758084616 | 3:135,809,448 | A/G | — | uncertain significance |
| rs4678322 | 3:135,812,523 | G/T | intron variant | — |
| rs376086206 | 3:135,820,864 | C/G | — | uncertain significance |
| rs547640444 | 3:135,820,923 | A/G | — | uncertain significance |
Showing 100 of 119 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.