RASGRP3
RAS guanyl releasing protein 3
Summary
The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
Known Variants39 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2124437 | 2:33,682,737 | G/T | intron variant | association |
| rs13385731 | 2:33,701,890 | T/C | regulatory region variant | — |
| rs13425999 | 2:33,702,203 | C/T | intron variant | — |
| rs528323494 | 2:33,741,707 | T/G | — | uncertain significance |
| rs200007507 | 2:33,745,019 | G/A | — | uncertain significance |
| rs369611073 | 2:33,745,024 | G/A | — | likely benign |
| rs781152306 | 2:33,745,076 | C/T | — | likely benign |
| rs369357266 | 2:33,745,732 | C/T | — | uncertain significance |
| rs2465602833 | 2:33,747,040 | G/A | — | uncertain significance |
| rs189837410 | 2:33,747,070 | C/T | — | benign |
| rs2465617545 | 2:33,749,105 | A/G | — | uncertain significance |
| rs564758640 | 2:33,749,109 | A/G | — | uncertain significance |
| rs2465617652 | 2:33,749,114 | G/A | — | uncertain significance |
| rs1251452351 | 2:33,749,572 | G/A | — | uncertain significance |
| rs1191968157 | 2:33,752,252 | A/C | — | uncertain significance |
| rs200209664 | 2:33,752,253 | A/G | — | uncertain significance |
| rs2465639386 | 2:33,752,262 | A/G | — | uncertain significance |
| rs751571321 | 2:33,752,273 | G/A | — | uncertain significance |
| rs749120154 | 2:33,752,287 | C/G | — | uncertain significance |
| rs34636269 | 2:33,752,299 | C/A | — | likely benign |
| rs1289925037 | 2:33,759,417 | G/C | — | uncertain significance |
| rs200573011 | 2:33,764,243 | C/A | — | uncertain significance |
| rs748338356 | 2:33,768,595 | A/G | — | uncertain significance |
| rs371780555 | 2:33,768,666 | G/A | — | uncertain significance |
| rs10209773 | 2:33,774,450 | C/G | — | — |
| rs2465794915 | 2:33,774,733 | A/G | — | uncertain significance |
| rs376375359 | 2:33,774,776 | G/T | — | uncertain significance |
| rs1574485216 | 2:33,774,779 | C/T | — | likely benign |
| rs1447722683 | 2:33,783,290 | A/G | — | uncertain significance |
| rs375130686 | 2:33,783,344 | G/A | — | uncertain significance |
| rs192400130 | 2:33,783,392 | C/G | — | uncertain significance |
| rs2465846416 | 2:33,783,754 | T/C | — | uncertain significance |
| rs1558529353 | 2:33,783,813 | G/A | — | uncertain significance |
| rs369191574 | 2:33,783,825 | T/C | — | uncertain significance |
| rs1372082644 | 2:33,783,828 | C/T | — | uncertain significance |
| rs766058863 | 2:33,783,964 | C/T | — | uncertain significance |
| rs1676324266 | 2:33,783,984 | G/T | — | uncertain significance |
| rs1322499215 | 2:33,784,015 | A/G | — | uncertain significance |
| rs376854458 | 2:33,784,038 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.