rs13385731
This is a regulatory region variant variant in the RASGRP3 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
systemic lupus erythematosus
Yin X et al. “Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus.” Annals of the Rheumatic Diseases 80(5):632-640 (2021)
Allele A
OR 1.29
p 1.0e-33
N 208,370
Meta-analysisLarge GWAS
East Asian
Han JW et al. “Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.” Nature Genetics 41(11):1234-7 (2009)
Allele A
OR 1.43
p 1.0e-15
N 2,252
Large GWAS
East Asian
total blood protein measurement
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.03
p 2.0e-20
N 448,242
Large GWAS
multi-ancestry
About RASGRP3
The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
View all RASGRP3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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