RIPK2

receptor interacting serine/threonine kinase 2

Summary

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

Known Variants26 total

rsidPosition (GRCh37)AllelesClassClinVar
rs24878924788:90,770,434T/Guncertain significance
rs397618:90,772,920T/Cupstream gene variant
rs13740828778:90,775,152T/Guncertain significance
rs2007368548:90,775,183T/Clikely benign
rs2008181008:90,775,193A/Guncertain significance
rs9998259398:90,777,711A/Guncertain significance
rs424908:90,778,513G/Aintron variantuncertain risk allele
rs7663088338:90,782,028G/Auncertain significance
rs7516213428:90,782,030A/Guncertain significance
rs1417686978:90,782,031T/Cuncertain significance
rs562577218:90,782,128A/Tbenign
rs14202966848:90,784,990G/Auncertain significance
rs3685381688:90,784,993C/Tuncertain significance
rs7663849528:90,784,994G/Alikely benign
rs350046678:90,785,005C/Gbenign
rs18093360028:90,785,018G/Auncertain significance
rs12805037568:90,792,384C/Tuncertain significance
rs1998508698:90,796,347G/Auncertain significance
rs24879485498:90,798,855G/Cuncertain significance
rs3682316008:90,801,572A/Guncertain significance
rs9948360458:90,801,644T/Cuncertain significance
rs2003971358:90,801,695A/Glikely benign
rs2007699688:90,802,346G/Auncertain significance
rs1513034698:90,802,397C/Tuncertain significance
rs24879561968:90,802,477A/Guncertain significance
rs404578:90,823,687A/Gintergenic variantuncertain risk allele

Gene information from NCBI Gene. Variant classifications from ClinVar.