rs39761
This is a upstream gene variant variant in the RIPK2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
leprosy
Jung S et al. “Identification of shared loci associated with both Crohn's disease and leprosy in East Asians.” Human Molecular Genetics 31(22):3934-3944 (2022)
Allele T
OR 1.31
p 1.0e-12
N 4,940
Large GWAS
East Asian
About RIPK2
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
View all RIPK2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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