SH3YL1

SH3 and SYLF domain containing 1

Summary

Enables phosphatase binding activity and phosphatidylinositol binding activity. Predicted to be involved in regulation of ruffle assembly. Predicted to act upstream of or within phosphatidylinositol biosynthetic process. Located in ruffle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants32 total

rsidPosition (GRCh37)AllelesClassClinVar
rs3741877552:218,888A/Guncertain significance
rs8899715392:218,902A/Guncertain significance
rs7468987912:218,971G/Auncertain significance
rs7478763722:218,982T/Cuncertain significance
rs25276197242:218,984T/Cuncertain significance
rs76019442:229,456A/Gintron variant
rs9436715472:230,011G/Auncertain significance
rs1384475252:230,540G/Tintron variant
rs7686820512:231,066C/Tuncertain significance
rs3686060572:231,115A/Guncertain significance
rs3722480852:231,124C/Tuncertain significance
rs9688371122:231,127C/Tuncertain significance
rs14396758962:231,136G/Tuncertain significance
rs7803151752:231,138C/Tuncertain significance
rs5603429932:231,139G/Auncertain significance
rs2002227542:231,144G/Alikely benign
rs5492752002:231,161G/Tuncertain significance
rs1438303392:233,182G/Auncertain significance
rs16681263502:233,183T/Guncertain significance
rs3732050952:233,213C/Auncertain significance
rs7521526522:233,215T/Guncertain significance
rs3774229692:233,229C/Auncertain significance
rs5314080742:234,197C/Tuncertain significance
rs7611151052:234,239G/Auncertain significance
rs67100912:239,597C/Gintron variant
rs177135682:242,132G/Aintron variant
rs621145052:242,426A/Gintron variant
rs7744474032:247,601T/Guncertain significance
rs3770957012:249,748G/Auncertain significance
rs7801194352:249,839C/Tuncertain significance
rs12499294402:253,013A/Tuncertain significance
rs7778784512:253,112T/Cuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.