SORCS2
sortilin related VPS10 domain containing receptor 2
Summary
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. [provided by RefSeq, Jul 2008]
Known Variants152 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1379531032 | 4:7,194,381 | A/C | — | uncertain significance |
| rs941954703 | 4:7,194,408 | G/T | — | uncertain significance |
| rs1047727737 | 4:7,194,410 | C/T | — | uncertain significance |
| rs891166809 | 4:7,194,417 | C/T | — | uncertain significance |
| rs1249328324 | 4:7,194,419 | A/C | — | uncertain significance |
| rs1008228480 | 4:7,194,420 | C/G | — | uncertain significance |
| rs1329626385 | 4:7,194,426 | G/A | — | uncertain significance |
| rs1032192515 | 4:7,194,429 | C/A | — | uncertain significance |
| rs1249364874 | 4:7,194,432 | C/G | — | uncertain significance |
| rs956704380 | 4:7,194,443 | G/A | — | uncertain significance |
| rs970393286 | 4:7,194,452 | C/T | — | uncertain significance |
| rs1334099518 | 4:7,194,458 | C/T | — | uncertain significance |
| rs1726918662 | 4:7,194,471 | C/T | — | uncertain significance |
| rs2549572882 | 4:7,194,504 | G/C | — | uncertain significance |
| rs2549572940 | 4:7,194,531 | C/T | — | uncertain significance |
| rs1204516098 | 4:7,194,561 | A/C | — | uncertain significance |
| rs1291339142 | 4:7,194,593 | G/A | — | uncertain significance |
| rs1305255915 | 4:7,194,608 | G/A | — | uncertain significance |
| rs558449809 | 4:7,194,810 | C/G | — | uncertain significance |
| rs755766111 | 4:7,194,837 | C/T | — | uncertain significance |
| rs4234798 | 4:7,219,933 | T/G | regulatory region variant | — |
| rs576573069 | 4:7,225,613 | T/G | — | — |
| rs530032000 | 4:7,232,298 | T/C | — | — |
| rs557743554 | 4:7,248,370 | T/C | — | — |
| rs6812479 | 4:7,255,094 | T/G | — | — |
| rs141585287 | 4:7,257,193 | G/A | regulatory region variant | — |
| rs141674098 | 4:7,258,377 | G/T | intron variant | — |
| rs3846421 | 4:7,285,356 | G/C | — | — |
| rs4689699 | 4:7,315,187 | A/G | downstream gene variant | — |
| rs531563674 | 4:7,320,049 | A/C | — | — |
| rs138588594 | 4:7,320,648 | C/T | intron variant | — |
| rs80094136 | 4:7,373,686 | G/C | regulatory region variant | — |
| rs561604195 | 4:7,389,209 | C/T | — | — |
| rs201499150 | 4:7,398,031 | C/T | — | uncertain significance |
| rs528646889 | 4:7,398,044 | C/G | — | uncertain significance |
| rs10034552 | 4:7,401,310 | C/T | intron variant | — |
| rs143074208 | 4:7,417,784 | G/A | intron variant | — |
| rs139862842 | 4:7,421,960 | C/T | intron variant | — |
| rs7694661 | 4:7,423,751 | C/A | intron variant | — |
| rs542453034 | 4:7,427,190 | C/T | — | — |
| rs183804815 | 4:7,429,207 | C/T | downstream gene variant | — |
| rs10021546 | 4:7,431,628 | C/T | downstream gene variant | — |
| rs58274198 | 4:7,432,600 | C/T | 3 prime UTR variant | — |
| rs74563302 | 4:7,433,091 | G/A | — | — |
| rs558939582 | 4:7,434,270 | C/T | — | — |
| rs199512404 | 4:7,436,080 | C/T | missense variant | — |
| rs77191210 | 4:7,436,701 | C/T | regulatory region variant | — |
| rs140402034 | 4:7,437,140 | C/G | upstream gene variant | — |
| rs28613646 | 4:7,437,413 | C/T | upstream gene variant | — |
| rs143941212 | 4:7,438,657 | C/T | upstream gene variant | — |
| rs149468682 | 4:7,439,556 | C/T | upstream gene variant | — |
| rs147673914 | 4:7,445,447 | T/C | intron variant | — |
| rs527891677 | 4:7,456,714 | G/A | — | — |
| rs6818195 | 4:7,460,713 | C/T | upstream gene variant | — |
| rs191752009 | 4:7,462,015 | C/T | downstream gene variant | — |
| rs150892437 | 4:7,475,806 | C/T | intron variant | — |
| rs10937823 | 4:7,480,422 | C/A | — | — |
| rs527321767 | 4:7,481,760 | G/A | — | — |
| rs150601080 | 4:7,484,602 | T/C | intron variant | — |
| rs545202789 | 4:7,487,862 | C/T | — | — |
| rs564817747 | 4:7,494,330 | T/C | — | — |
| rs35589546 | 4:7,527,687 | T/A | — | — |
| rs150440148 | 4:7,533,308 | C/G | — | benign |
| rs368456515 | 4:7,533,318 | A/G | — | uncertain significance |
| rs6812745 | 4:7,534,603 | A/G | intron variant | — |
| rs11729483 | 4:7,635,042 | C/T | intron variant | — |
| rs754954700 | 4:7,640,058 | A/G | — | uncertain significance |
| rs35727450 | 4:7,640,086 | G/A | — | uncertain significance |
| rs527549780 | 4:7,640,109 | G/A | — | likely benign |
| rs150055977 | 4:7,640,198 | C/T | — | benign |
| rs375792061 | 4:7,655,900 | C/A | — | uncertain significance |
| rs758478415 | 4:7,666,086 | G/A | — | likely benign |
| rs370112934 | 4:7,666,131 | C/T | — | uncertain significance |
| rs114808144 | 4:7,666,141 | C/G | — | uncertain significance |
| rs534049849 | 4:7,666,149 | C/A | — | uncertain significance |
| rs1481689191 | 4:7,666,157 | C/T | — | uncertain significance |
| rs757234955 | 4:7,666,159 | C/A | — | uncertain significance |
| rs377584831 | 4:7,666,172 | G/A | — | uncertain significance |
| rs77455588 | 4:7,668,881 | G/A | — | uncertain significance |
| rs368388764 | 4:7,668,939 | A/G | — | uncertain significance |
| rs186607625 | 4:7,677,550 | C/T | intron variant | — |
| rs369993013 | 4:7,677,785 | G/C | — | uncertain significance |
| rs775503463 | 4:7,677,811 | T/C | — | uncertain significance |
| rs770519056 | 4:7,677,879 | G/T | — | uncertain significance |
| rs766842106 | 4:7,677,909 | C/A | — | uncertain significance |
| rs754337600 | 4:7,677,910 | G/A | — | uncertain significance |
| rs756903443 | 4:7,677,925 | C/T | — | uncertain significance |
| rs1723606056 | 4:7,684,491 | T/C | — | uncertain significance |
| rs748970355 | 4:7,684,509 | A/C | — | uncertain significance |
| rs376699925 | 4:7,684,528 | C/T | — | uncertain significance |
| rs200362072 | 4:7,684,552 | G/A | — | uncertain significance |
| rs369677353 | 4:7,684,554 | G/A | — | uncertain significance |
| rs1311934497 | 4:7,684,594 | G/T | — | uncertain significance |
| rs4689821 | 4:7,684,661 | C/A | intron variant | — |
| rs111339092 | 4:7,691,248 | A/C | — | benign |
| rs750453288 | 4:7,691,268 | G/T | — | uncertain significance |
| rs749702077 | 4:7,691,274 | T/C | — | uncertain significance |
| rs1316070983 | 4:7,691,301 | T/C | — | uncertain significance |
| rs764006937 | 4:7,691,306 | A/G | — | uncertain significance |
| rs148375140 | 4:7,705,045 | C/T | — | benign |
Showing 100 of 152 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.