SYNE3
spectrin repeat containing nuclear envelope family member 3
Summary
Enables actin filament binding activity and cytoskeleton-nuclear membrane anchor activity. Involved in cytoskeleton organization; establishment of protein localization to membrane; and regulation of cell shape. Located in nuclear membrane. Part of meiotic nuclear membrane microtubule tethering complex. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants88 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs368574040 | 14:95,884,200 | G/A | — | uncertain significance |
| rs146368343 | 14:95,884,209 | C/T | — | uncertain significance |
| rs150752116 | 14:95,884,225 | C/A | — | uncertain significance |
| rs1331833780 | 14:95,884,236 | C/T | — | uncertain significance |
| rs746262942 | 14:95,884,330 | G/A | — | uncertain significance |
| rs12895389 | 14:95,892,274 | G/A | intron variant | — |
| rs375503107 | 14:95,898,432 | G/A | — | uncertain significance |
| rs764273195 | 14:95,898,433 | G/A | — | uncertain significance |
| rs569529532 | 14:95,899,647 | A/G | — | uncertain significance |
| rs1311917143 | 14:95,899,663 | C/A | — | uncertain significance |
| rs370756236 | 14:95,899,686 | G/A | — | uncertain significance |
| rs769804447 | 14:95,899,713 | G/C | — | uncertain significance |
| rs542033506 | 14:95,899,734 | G/A | — | uncertain significance |
| rs1886111527 | 14:95,903,191 | G/A | — | uncertain significance |
| rs764511039 | 14:95,903,302 | T/C | — | uncertain significance |
| rs146407791 | 14:95,905,377 | C/T | — | uncertain significance |
| rs779552067 | 14:95,905,397 | C/T | — | uncertain significance |
| rs1346505286 | 14:95,905,453 | T/G | — | uncertain significance |
| rs765212058 | 14:95,905,458 | G/A | — | uncertain significance |
| rs759033948 | 14:95,905,486 | A/C | — | uncertain significance |
| rs2503734084 | 14:95,905,995 | C/A | — | uncertain significance |
| rs2503734197 | 14:95,906,015 | T/G | — | uncertain significance |
| rs572478808 | 14:95,906,022 | C/T | — | uncertain significance |
| rs748337224 | 14:95,906,024 | G/A | — | uncertain significance |
| rs371647696 | 14:95,906,102 | G/A | — | uncertain significance |
| rs749577390 | 14:95,906,259 | C/T | — | uncertain significance |
| rs2139392745 | 14:95,906,264 | T/C | — | uncertain significance |
| rs756639179 | 14:95,906,301 | G/A | — | uncertain significance |
| rs188418564 | 14:95,906,374 | G/C | — | uncertain significance |
| rs767003225 | 14:95,906,394 | G/A | — | uncertain significance |
| rs771649997 | 14:95,909,541 | T/C | — | uncertain significance |
| rs372953935 | 14:95,909,576 | C/A | — | uncertain significance |
| rs200840336 | 14:95,909,607 | A/T | — | uncertain significance |
| rs750472860 | 14:95,909,616 | T/C | — | uncertain significance |
| rs565608397 | 14:95,910,934 | G/A | — | uncertain significance |
| rs772601950 | 14:95,910,965 | T/C | — | uncertain significance |
| rs556818166 | 14:95,912,258 | T/G | — | uncertain significance |
| rs147178428 | 14:95,912,322 | A/C | — | uncertain significance |
| rs921795608 | 14:95,912,326 | G/A | — | uncertain significance |
| rs764945000 | 14:95,912,331 | G/A | — | likely benign |
| rs769690758 | 14:95,912,407 | G/A | — | uncertain significance |
| rs147345417 | 14:95,912,414 | T/A | — | uncertain significance |
| rs754142966 | 14:95,916,313 | G/C | — | uncertain significance |
| rs752841256 | 14:95,916,336 | G/C | — | uncertain significance |
| rs1419662487 | 14:95,916,341 | G/T | — | uncertain significance |
| rs913458748 | 14:95,916,344 | A/C | — | uncertain significance |
| rs756061434 | 14:95,916,377 | C/T | — | uncertain significance |
| rs531457245 | 14:95,918,635 | T/C | — | uncertain significance |
| rs146532718 | 14:95,918,677 | C/T | — | uncertain significance |
| rs149220293 | 14:95,918,678 | G/A | — | uncertain significance |
| rs143414368 | 14:95,918,687 | G/A | — | uncertain significance |
| rs749768826 | 14:95,918,714 | G/A | — | uncertain significance |
| rs770975616 | 14:95,921,730 | T/C | — | likely benign |
| rs776715451 | 14:95,921,732 | T/C | — | likely benign |
| rs771184132 | 14:95,921,733 | G/T | — | uncertain significance |
| rs781208017 | 14:95,921,734 | C/T | — | uncertain significance |
| rs375467304 | 14:95,921,743 | C/T | — | uncertain significance |
| rs778187503 | 14:95,921,757 | G/A | — | uncertain significance |
| rs770607613 | 14:95,921,880 | C/T | — | likely benign |
| rs199497782 | 14:95,921,887 | G/A | — | uncertain significance |
| rs567096806 | 14:95,921,911 | C/T | — | uncertain significance |
| rs200001831 | 14:95,921,965 | C/T | — | uncertain significance |
| rs148687059 | 14:95,921,988 | C/T | — | likely benign |
| rs376547031 | 14:95,923,530 | C/T | — | uncertain significance |
| rs202183573 | 14:95,923,557 | C/T | — | uncertain significance |
| rs199883369 | 14:95,923,625 | C/G | — | uncertain significance |
| rs763785289 | 14:95,923,671 | C/T | — | uncertain significance |
| rs751183434 | 14:95,923,672 | G/A | — | uncertain significance |
| rs768455712 | 14:95,932,324 | C/T | — | uncertain significance |
| rs1367247171 | 14:95,932,476 | A/T | — | uncertain significance |
| rs767772253 | 14:95,932,516 | G/A | — | uncertain significance |
| rs1444046025 | 14:95,932,521 | A/G | — | uncertain significance |
| rs201418759 | 14:95,934,192 | C/T | — | likely benign |
| rs148002580 | 14:95,934,253 | G/A | — | uncertain significance |
| rs770091322 | 14:95,934,270 | C/T | — | likely benign |
| rs376779070 | 14:95,934,283 | C/T | — | uncertain significance |
| rs1354275623 | 14:95,934,297 | C/T | — | uncertain significance |
| rs776529744 | 14:95,942,017 | C/T | — | uncertain significance |
| rs1245147199 | 14:95,942,035 | C/T | — | uncertain significance |
| rs756698494 | 14:95,942,043 | G/A | — | uncertain significance |
| rs370244222 | 14:95,942,058 | T/C | — | uncertain significance |
| rs993631512 | 14:95,942,104 | A/G | — | uncertain significance |
| rs200309130 | 14:95,942,112 | G/A | — | uncertain significance |
| rs758563267 | 14:95,942,145 | G/A | — | uncertain significance |
| rs11622887 | 14:95,942,447 | A/C | upstream gene variant | — |
| rs734313 | 14:95,956,572 | G/C | intergenic variant | — |
| rs179151 | 14:95,981,829 | G/C | — | — |
| rs179146 | 14:95,983,898 | A/T | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.