TESK2
testis associated actin remodelling kinase 2
Summary
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs566882803 | 1:45,810,552 | G/A | — | uncertain significance |
| rs958060494 | 1:45,810,660 | C/G | — | uncertain significance |
| rs778652066 | 1:45,810,729 | C/T | — | uncertain significance |
| rs201896771 | 1:45,810,730 | G/A | — | uncertain significance |
| rs186592461 | 1:45,810,774 | C/T | — | likely benign |
| rs2524814430 | 1:45,810,841 | A/T | — | uncertain significance |
| rs749656797 | 1:45,810,849 | G/A | — | uncertain significance |
| rs372877245 | 1:45,810,864 | C/T | — | uncertain significance |
| rs17853159 | 1:45,810,865 | A/G | — | benign |
| rs753719830 | 1:45,810,870 | C/T | — | uncertain significance |
| rs573693701 | 1:45,810,874 | G/A | — | uncertain significance |
| rs200035854 | 1:45,810,915 | A/G | — | uncertain significance |
| rs780384466 | 1:45,811,041 | G/A | — | uncertain significance |
| rs373750301 | 1:45,811,107 | C/T | — | uncertain significance |
| rs368634063 | 1:45,811,149 | C/T | — | uncertain significance |
| rs1319621583 | 1:45,811,197 | A/G | — | uncertain significance |
| rs778883567 | 1:45,811,550 | C/G | — | uncertain significance |
| rs780678665 | 1:45,811,551 | C/G | — | uncertain significance |
| rs187399031 | 1:45,811,616 | C/A | — | uncertain significance |
| rs760597513 | 1:45,812,667 | T/C | — | uncertain significance |
| rs755123085 | 1:45,813,597 | C/T | — | uncertain significance |
| rs368533762 | 1:45,821,036 | A/G | — | uncertain significance |
| rs1304318198 | 1:45,821,055 | C/G | — | uncertain significance |
| rs1355620972 | 1:45,821,120 | T/C | — | uncertain significance |
| rs118083851 | 1:45,835,387 | T/A | intron variant | — |
| rs1538970 | 1:45,847,562 | G/T | — | — |
| rs61791369 | 1:45,870,279 | G/C | — | — |
| rs368627237 | 1:45,887,423 | A/T | — | uncertain significance |
| rs372388070 | 1:45,887,458 | G/A | — | uncertain significance |
| rs781563700 | 1:45,887,505 | G/C | — | uncertain significance |
| rs12410493 | 1:45,902,048 | G/A | intron variant | — |
| rs55642258 | 1:45,916,061 | G/A | intron variant | — |
| rs2149300023 | 1:45,923,330 | T/C | — | uncertain significance |
| rs757425136 | 1:45,923,340 | G/A | — | uncertain significance |
| rs772840123 | 1:45,923,421 | G/A | — | uncertain significance |
| rs12564806 | 1:45,924,230 | C/T | intron variant | — |
| rs2055145 | 1:45,926,495 | C/G | intron variant | — |
| rs12138348 | 1:45,939,136 | C/T | intron variant | — |
| rs12037201 | 1:45,941,349 | G/C | — | — |
| rs4660861 | 1:45,946,636 | G/T | intron variant | — |
| rs11211123 | 1:45,957,609 | G/A | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.