TNS1

tensin 1

Summary

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Known Variants216 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs182851722	2:218,669,173	G/A	—	likely benign
rs143428830	2:218,669,196	C/T	—	uncertain significance
rs371606202	2:218,669,218	G/A	—	likely benign
rs61741262	2:218,669,225	C/T	—	benign
rs746718057	2:218,669,279	G/T	—	uncertain significance
rs61740057	2:218,669,281	G/A	—	benign
rs61740054	2:218,669,288	G/A	—	likely benign
rs371968350	2:218,669,314	G/A	—	likely benign
rs377079698	2:218,669,334	C/A	—	likely benign
rs200822159	2:218,669,335	G/A	—	likely benign
rs779217268	2:218,673,380	C/T	—	uncertain significance
rs373152875	2:218,673,398	C/A	—	likely benign
rs201730716	2:218,674,598	C/T	—	uncertain significance
rs758979599	2:218,674,615	G/A	—	uncertain significance
rs918949	2:218,674,697	T/C	—	benign
rs1035673	2:218,675,533	T/C	intron variant	—
rs2469497353	2:218,677,138	G/A	—	uncertain significance
rs76043829	2:218,677,586	G/A	intron variant	—
rs375433855	2:218,677,952	T/C	—	uncertain significance
rs2469510823	2:218,677,989	T/C	—	uncertain significance
rs2469510852	2:218,677,990	C/A	—	uncertain significance
rs202014996	2:218,678,422	T/G	—	uncertain significance
rs775670202	2:218,678,425	A/T	—	uncertain significance
rs2469520048	2:218,678,486	G/A	—	uncertain significance
rs760310159	2:218,678,537	T/C	—	uncertain significance
rs144860480	2:218,679,712	G/C	—	uncertain significance
rs2469535070	2:218,679,718	T/C	—	uncertain significance
rs763402455	2:218,682,437	C/T	—	uncertain significance
rs148598641	2:218,682,438	G/A	—	likely benign
rs775043696	2:218,682,439	G/T	—	uncertain significance
rs187403005	2:218,682,462	G/A	—	likely benign
rs12694422	2:218,682,474	G/A	—	benign
rs149122582	2:218,682,492	G/A	—	likely benign
rs61746065	2:218,682,497	C/T	—	benign
rs61746069	2:218,682,504	C/T	—	benign
rs143109214	2:218,682,509	A/C	—	uncertain significance
rs1317712411	2:218,682,535	T/C	—	uncertain significance
rs761632833	2:218,682,619	G/A	—	uncertain significance
rs143531869	2:218,682,620	C/T	—	benign
rs753791826	2:218,682,715	G/A	—	uncertain significance
rs565596219	2:218,682,749	G/A	—	uncertain significance
rs140104262	2:218,682,757	G/A	—	likely benign
rs3796026	2:218,682,771	A/G	—	benign
rs533811485	2:218,682,838	C/T	—	uncertain significance
rs555032914	2:218,682,839	G/A	—	uncertain significance
rs150663283	2:218,682,888	G/A	—	likely benign
rs140195511	2:218,682,923	G/T	—	benign
rs1942228832	2:218,682,953	C/T	—	uncertain significance
rs189777473	2:218,683,026	G/T	—	likely benign
rs1942251825	2:218,683,046	G/T	—	uncertain significance
rs149865301	2:218,683,055	C/G	—	uncertain significance
rs771628959	2:218,683,058	T/C	—	uncertain significance
rs376418427	2:218,683,075	G/A	—	uncertain significance
rs776119921	2:218,683,087	C/G	—	uncertain significance
rs34291329	2:218,683,139	G/A	—	benign
rs369393471	2:218,683,150	C/T	—	likely benign
rs2571445	2:218,683,154	A/G	missense variant	benign
rs749605553	2:218,683,177	G/T	—	uncertain significance
rs767473683	2:218,683,201	C/T	—	uncertain significance
rs2552525	2:218,683,203	C/T	—	benign
rs549005226	2:218,683,204	G/A	—	uncertain significance
rs138956630	2:218,683,225	G/A	—	uncertain significance
rs146394470	2:218,683,233	G/A	—	benign
rs2469018060	2:218,683,234	C/T	—	uncertain significance
rs1473628701	2:218,683,255	C/T	—	uncertain significance
rs2571442	2:218,683,257	A/G	—	benign
rs1942302832	2:218,683,264	C/T	—	uncertain significance
rs760755214	2:218,683,269	C/T	—	likely benign
rs375633988	2:218,683,270	G/A	—	benign
rs1170588432	2:218,683,271	G/T	—	uncertain significance
rs184451758	2:218,683,301	C/T	—	likely benign
rs34144104	2:218,683,368	C/T	—	benign
rs61745431	2:218,683,396	C/T	—	benign
rs201310757	2:218,683,402	C/A	—	uncertain significance
rs753614446	2:218,683,414	A/T	—	uncertain significance
rs375025312	2:218,683,458	C/T	—	likely benign
rs374099297	2:218,686,486	G/A	—	likely benign
rs77931866	2:218,686,529	G/T	—	benign
rs778953855	2:218,686,545	G/A	—	uncertain significance
rs745791045	2:218,686,593	G/A	—	uncertain significance
rs1347992348	2:218,686,611	G/C	—	uncertain significance
rs768382919	2:218,686,625	G/A	—	uncertain significance
rs370481778	2:218,686,632	G/A	—	uncertain significance
rs112371945	2:218,686,643	T/A	—	benign
rs142672992	2:218,686,655	C/T	—	uncertain significance
rs779322372	2:218,686,656	G/A	—	uncertain significance
rs1944242077	2:218,695,098	A/G	—	uncertain significance
rs3796028	2:218,695,102	G/A	—	benign
rs780854400	2:218,696,183	G/A	—	uncertain significance
rs2552530	2:218,696,215	A/G	—	benign
rs373055196	2:218,696,267	C/T	—	uncertain significance
rs542492773	2:218,696,268	G/A	—	uncertain significance
rs145825540	2:218,699,819	C/T	—	uncertain significance
rs201800226	2:218,699,832	T/C	—	likely benign
rs2469185823	2:218,699,861	A/G	—	uncertain significance
rs772869891	2:218,699,880	G/A	—	uncertain significance
rs1259777988	2:218,700,748	C/T	—	uncertain significance
rs143523583	2:218,700,767	C/T	—	likely benign
rs61743061	2:218,700,768	G/A	—	benign
rs752044847	2:218,700,787	G/A	—	uncertain significance

Showing 100 of 216 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.