TNS2

tensin 2

Summary

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Known Variants334 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs7304594	12:53,441,607	C/T	regulatory region variant	—
rs12368584	12:53,442,129	C/T	regulatory region variant	—
rs12369033	12:53,442,956	G/C	—	benign
rs2539601362	12:53,442,999	G/A	—	likely benign
rs201457662	12:53,443,041	C/T	—	likely benign
rs2539601542	12:53,443,047	T/C	—	likely benign
rs148652257	12:53,443,049	G/C	—	benign
rs11170385	12:53,443,278	T/G	regulatory region variant	—
rs149801196	12:53,444,004	G/A	—	uncertain significance
rs749029842	12:53,444,007	C/T	—	likely benign
rs770513070	12:53,444,035	C/G	—	likely benign
rs181126368	12:53,445,650	T/G	—	likely benign
rs140534652	12:53,445,667	G/A	—	uncertain significance
rs147085802	12:53,445,677	T/C	—	likely benign
rs751421693	12:53,445,689	A/T	—	uncertain significance
rs113829803	12:53,445,704	A/G	—	conflicting classifications of pathogenicity
rs531569772	12:53,445,754	C/T	—	benign
rs10783560	12:53,445,959	T/C	—	benign
rs370897636	12:53,446,252	G/A	—	likely benign
rs761614391	12:53,446,255	G/A	—	likely benign
rs1433510501	12:53,446,279	G/A	—	uncertain significance
rs760514195	12:53,447,182	G/A	—	uncertain significance
rs138594065	12:53,447,185	C/T	—	benign
rs372071424	12:53,447,188	C/T	—	likely benign
rs1479210542	12:53,447,204	G/T	—	uncertain significance
rs1231949743	12:53,447,215	C/G	—	likely benign
rs199604341	12:53,447,225	G/A	—	uncertain significance
rs547347317	12:53,447,236	G/A	—	uncertain significance
rs199865868	12:53,447,242	G/A	—	benign
rs749282867	12:53,447,248	G/C	—	likely benign
rs199876788	12:53,447,568	C/T	—	likely benign
rs143157473	12:53,447,571	C/T	—	uncertain significance
rs2539620790	12:53,447,573	C/T	—	uncertain significance
rs1277747710	12:53,447,576	G/T	—	uncertain significance
rs1045470481	12:53,447,580	G/A	—	uncertain significance
rs754335618	12:53,447,583	G/A	—	uncertain significance
rs148710187	12:53,447,733	G/A	—	likely benign
rs2539621828	12:53,447,767	A/G	—	uncertain significance
rs761408727	12:53,447,808	G/A	—	likely benign
rs754217469	12:53,447,813	T/A	—	likely benign
rs535459703	12:53,447,817	G/T	—	likely benign
rs1944049662	12:53,448,107	A/G	—	uncertain significance
rs141470860	12:53,448,114	G/A	—	likely benign
rs1211810026	12:53,448,124	T/G	—	uncertain significance
rs780031234	12:53,448,141	C/T	—	likely benign
rs146960728	12:53,448,149	C/T	—	uncertain significance
rs373949417	12:53,448,166	C/T	—	uncertain significance
rs1455298498	12:53,448,184	C/T	—	likely benign
rs771514984	12:53,448,193	G/A	—	uncertain significance
rs188102991	12:53,448,211	C/G	—	uncertain significance
rs568025314	12:53,448,219	G/C	—	uncertain significance
rs201142870	12:53,448,235	G/A	—	benign
rs11170386	12:53,448,320	C/T	—	benign
rs749623043	12:53,448,984	A/G	—	likely benign
rs754040003	12:53,449,026	A/T	—	uncertain significance
rs7315980	12:53,449,321	G/A	—	benign
rs2539630680	12:53,449,397	A/G	—	uncertain significance
rs2539630737	12:53,449,414	C/T	—	likely benign
rs538446852	12:53,449,432	G/T	—	uncertain significance
rs779774250	12:53,449,437	G/A	—	uncertain significance
rs745972332	12:53,449,457	G/A	—	uncertain significance
rs377288328	12:53,449,459	C/G	—	likely benign
rs763199154	12:53,449,460	G/A	—	uncertain significance
rs568862039	12:53,449,463	C/T	—	likely benign
rs2293062	12:53,449,597	T/C	—	benign
rs2364153	12:53,449,735	T/C	—	benign
rs1944183225	12:53,450,778	C/G	—	uncertain significance
rs776215521	12:53,450,799	C/T	—	uncertain significance
rs201049250	12:53,450,800	G/A	—	likely benign
rs540051071	12:53,450,828	C/T	—	conflicting classifications of pathogenicity
rs1335904355	12:53,450,840	G/A	—	uncertain significance
rs755085040	12:53,450,847	A/G	—	uncertain significance
rs374077358	12:53,450,852	G/A	—	uncertain significance
rs373364251	12:53,450,862	T/A	—	uncertain significance
rs746785173	12:53,450,865	A/G	—	uncertain significance
rs553308233	12:53,450,876	C/T	—	uncertain significance
rs1033348137	12:53,451,360	C/T	—	likely benign
rs148121884	12:53,451,375	G/A	—	likely benign
rs757611065	12:53,451,432	C/A	—	likely benign
rs1209156050	12:53,451,441	G/A	—	likely benign
rs755004811	12:53,451,537	C/T	—	likely benign
rs56215439	12:53,451,546	T/C	—	likely benign
rs773407573	12:53,451,566	C/A	—	uncertain significance
rs769210671	12:53,451,627	C/G	—	likely benign
rs2539638681	12:53,451,632	C/T	—	likely benign
rs1461425099	12:53,451,837	A/G	—	uncertain significance
rs11170389	12:53,451,849	G/C	—	benign
rs759397813	12:53,451,875	G/A	—	uncertain significance
rs151036307	12:53,451,877	C/T	—	benign
rs375008816	12:53,451,896	G/T	—	likely benign
rs2280446	12:53,451,952	T/C	—	benign
rs1226910524	12:53,452,105	A/G	—	likely benign
rs149747461	12:53,452,124	C/T	—	uncertain significance
rs73099910	12:53,452,130	A/G	—	uncertain significance
rs2539641047	12:53,452,149	T/G	—	uncertain significance
rs145598644	12:53,452,152	G/A	—	uncertain significance
rs139273379	12:53,452,217	G/A	—	conflicting classifications of pathogenicity
rs532244239	12:53,452,229	G/A	—	likely benign
rs2539642024	12:53,452,368	C/G	—	uncertain significance
rs374144803	12:53,452,381	C/T	—	likely benign

Showing 100 of 334 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.