TNS3
tensin 3
Summary
Predicted to enable guanyl-nucleotide exchange factor adaptor activity. Predicted to be involved in positive regulation of Rac protein signal transduction and positive regulation of guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within several processes, including bone resorption; negative regulation of Rho protein signal transduction; and podosome assembly. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants136 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs373269947 | 7:47,317,704 | C/T | — | benign |
| rs746385007 | 7:47,317,724 | T/C | — | uncertain significance |
| rs374197575 | 7:47,317,730 | T/C | — | uncertain significance |
| rs149017357 | 7:47,319,774 | C/T | — | likely benign |
| rs762026975 | 7:47,319,897 | G/A | — | uncertain significance |
| rs539978111 | 7:47,319,921 | T/C | — | uncertain significance |
| rs183336114 | 7:47,319,928 | G/A | — | benign |
| rs202189855 | 7:47,323,416 | C/T | — | uncertain significance |
| rs41280696 | 7:47,331,594 | G/A | — | likely benign |
| rs372093117 | 7:47,332,451 | C/A | — | likely benign |
| rs373172661 | 7:47,332,467 | G/A | — | uncertain significance |
| rs752923117 | 7:47,332,494 | G/A | — | uncertain significance |
| rs781604732 | 7:47,333,404 | G/A | — | likely benign |
| rs765369218 | 7:47,336,711 | G/A | — | likely benign |
| rs755646376 | 7:47,336,743 | C/A | — | uncertain significance |
| rs368424663 | 7:47,336,783 | C/T | — | likely benign |
| rs375685287 | 7:47,336,806 | C/T | — | uncertain significance |
| rs1786493279 | 7:47,342,553 | A/T | — | uncertain significance |
| rs199534852 | 7:47,342,556 | G/A | — | uncertain significance |
| rs1484225222 | 7:47,342,587 | C/T | — | uncertain significance |
| rs77924433 | 7:47,342,611 | T/A | — | benign |
| rs369933759 | 7:47,342,627 | G/A | — | likely benign |
| rs1250707892 | 7:47,342,637 | C/A | — | uncertain significance |
| rs572090721 | 7:47,342,691 | G/A | — | uncertain significance |
| rs188962919 | 7:47,342,713 | G/C | — | likely benign |
| rs370692650 | 7:47,342,784 | G/A | — | uncertain significance |
| rs202060822 | 7:47,342,785 | C/T | — | conflicting classifications of pathogenicity |
| rs181932240 | 7:47,342,790 | G/A | — | benign |
| rs761145574 | 7:47,342,821 | C/T | — | uncertain significance |
| rs61731307 | 7:47,342,844 | G/T | — | benign |
| rs373883298 | 7:47,342,858 | C/G | — | likely benign |
| rs755858323 | 7:47,342,899 | C/T | — | uncertain significance |
| rs571040304 | 7:47,342,906 | G/C | — | benign |
| rs2546867592 | 7:47,342,914 | G/A | — | uncertain significance |
| rs775769392 | 7:47,342,923 | C/T | — | uncertain significance |
| rs371933905 | 7:47,342,970 | G/A | — | uncertain significance |
| rs763839011 | 7:47,342,978 | G/T | — | likely benign |
| rs61731305 | 7:47,343,079 | A/G | — | benign |
| rs762851082 | 7:47,343,111 | C/A | — | uncertain significance |
| rs992180693 | 7:47,343,115 | C/A | — | uncertain significance |
| rs532951012 | 7:47,343,150 | C/T | — | uncertain significance |
| rs747449888 | 7:47,344,464 | T/C | — | likely benign |
| rs372436274 | 7:47,344,490 | T/C | — | uncertain significance |
| rs767289075 | 7:47,344,491 | G/T | — | uncertain significance |
| rs758690826 | 7:47,344,520 | C/A | — | uncertain significance |
| rs751955631 | 7:47,344,521 | G/A | — | uncertain significance |
| rs1223803012 | 7:47,344,542 | C/T | — | uncertain significance |
| rs368195055 | 7:47,344,593 | T/C | — | likely benign |
| rs7809597 | 7:47,375,200 | C/A | — | — |
| rs369259069 | 7:47,384,364 | T/C | — | uncertain significance |
| rs201802191 | 7:47,384,395 | G/T | — | uncertain significance |
| rs140241425 | 7:47,384,400 | G/A | — | benign |
| rs61731310 | 7:47,384,411 | C/T | — | benign |
| rs567120799 | 7:47,384,422 | G/A | — | uncertain significance |
| rs61731311 | 7:47,384,614 | T/C | — | uncertain significance |
| rs2547034865 | 7:47,384,636 | T/C | — | uncertain significance |
| rs189838492 | 7:47,384,646 | G/A | — | benign |
| rs758312682 | 7:47,385,790 | T/G | — | uncertain significance |
| rs201649683 | 7:47,385,793 | C/T | — | uncertain significance |
| rs201941233 | 7:47,385,798 | G/A | — | uncertain significance |
| rs562816834 | 7:47,385,816 | G/A | — | uncertain significance |
| rs2547042375 | 7:47,385,861 | T/C | — | uncertain significance |
| rs369305083 | 7:47,385,893 | G/C | — | uncertain significance |
| rs1030675984 | 7:47,385,909 | C/T | — | uncertain significance |
| rs1789341908 | 7:47,385,941 | T/G | — | likely benign |
| rs1328815474 | 7:47,407,990 | C/G | — | uncertain significance |
| rs1012552563 | 7:47,408,012 | C/T | — | uncertain significance |
| rs777401189 | 7:47,408,022 | G/A | — | uncertain significance |
| rs199938891 | 7:47,408,073 | C/T | — | uncertain significance |
| rs367961192 | 7:47,408,079 | C/T | — | likely benign |
| rs755592495 | 7:47,408,085 | T/C | — | uncertain significance |
| rs778645394 | 7:47,408,112 | G/C | — | uncertain significance |
| rs375273859 | 7:47,408,148 | T/A | — | uncertain significance |
| rs7808646 | 7:47,408,208 | C/T | — | benign |
| rs142175160 | 7:47,408,209 | G/A | — | likely benign |
| rs114488371 | 7:47,408,252 | G/A | — | benign |
| rs542060079 | 7:47,408,286 | G/T | — | uncertain significance |
| rs1030444116 | 7:47,408,331 | T/C | — | uncertain significance |
| rs765939820 | 7:47,408,355 | G/A | — | uncertain significance |
| rs758592604 | 7:47,408,381 | C/T | — | uncertain significance |
| rs562995079 | 7:47,408,409 | C/T | — | uncertain significance |
| rs367556254 | 7:47,408,414 | C/T | — | uncertain significance |
| rs1231145462 | 7:47,408,425 | A/T | — | uncertain significance |
| rs73326532 | 7:47,408,426 | T/C | — | benign |
| rs561389270 | 7:47,408,433 | C/T | — | uncertain significance |
| rs753083288 | 7:47,408,524 | G/A | — | likely benign |
| rs1790886257 | 7:47,408,597 | T/C | — | uncertain significance |
| rs375420968 | 7:47,408,605 | G/A | — | likely benign |
| rs376058370 | 7:47,408,627 | G/A | — | uncertain significance |
| rs552081357 | 7:47,408,645 | G/A | — | uncertain significance |
| rs139781998 | 7:47,408,718 | G/A | — | likely benign |
| rs776663402 | 7:47,408,735 | T/G | — | likely benign |
| rs949757871 | 7:47,408,753 | G/A | — | uncertain significance |
| rs143062302 | 7:47,408,782 | C/T | — | likely benign |
| rs747130033 | 7:47,408,802 | C/T | — | uncertain significance |
| rs764145645 | 7:47,408,826 | G/A | — | uncertain significance |
| rs761549994 | 7:47,408,884 | C/T | — | likely benign |
| rs200906390 | 7:47,408,900 | C/T | — | uncertain significance |
| rs1584499706 | 7:47,408,902 | A/G | — | likely benign |
| rs2547170714 | 7:47,409,042 | T/C | — | uncertain significance |
Showing 100 of 136 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.