TNS3

tensin 3

Summary

Predicted to enable guanyl-nucleotide exchange factor adaptor activity. Predicted to be involved in positive regulation of Rac protein signal transduction and positive regulation of guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within several processes, including bone resorption; negative regulation of Rho protein signal transduction; and podosome assembly. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Apr 2025]

Known Variants136 total

rsidPosition (GRCh37)AllelesClassClinVar
rs3732699477:47,317,704C/Tbenign
rs7463850077:47,317,724T/Cuncertain significance
rs3741975757:47,317,730T/Cuncertain significance
rs1490173577:47,319,774C/Tlikely benign
rs7620269757:47,319,897G/Auncertain significance
rs5399781117:47,319,921T/Cuncertain significance
rs1833361147:47,319,928G/Abenign
rs2021898557:47,323,416C/Tuncertain significance
rs412806967:47,331,594G/Alikely benign
rs3720931177:47,332,451C/Alikely benign
rs3731726617:47,332,467G/Auncertain significance
rs7529231177:47,332,494G/Auncertain significance
rs7816047327:47,333,404G/Alikely benign
rs7653692187:47,336,711G/Alikely benign
rs7556463767:47,336,743C/Auncertain significance
rs3684246637:47,336,783C/Tlikely benign
rs3756852877:47,336,806C/Tuncertain significance
rs17864932797:47,342,553A/Tuncertain significance
rs1995348527:47,342,556G/Auncertain significance
rs14842252227:47,342,587C/Tuncertain significance
rs779244337:47,342,611T/Abenign
rs3699337597:47,342,627G/Alikely benign
rs12507078927:47,342,637C/Auncertain significance
rs5720907217:47,342,691G/Auncertain significance
rs1889629197:47,342,713G/Clikely benign
rs3706926507:47,342,784G/Auncertain significance
rs2020608227:47,342,785C/Tconflicting classifications of pathogenicity
rs1819322407:47,342,790G/Abenign
rs7611455747:47,342,821C/Tuncertain significance
rs617313077:47,342,844G/Tbenign
rs3738832987:47,342,858C/Glikely benign
rs7558583237:47,342,899C/Tuncertain significance
rs5710403047:47,342,906G/Cbenign
rs25468675927:47,342,914G/Auncertain significance
rs7757693927:47,342,923C/Tuncertain significance
rs3719339057:47,342,970G/Auncertain significance
rs7638390117:47,342,978G/Tlikely benign
rs617313057:47,343,079A/Gbenign
rs7628510827:47,343,111C/Auncertain significance
rs9921806937:47,343,115C/Auncertain significance
rs5329510127:47,343,150C/Tuncertain significance
rs7474498887:47,344,464T/Clikely benign
rs3724362747:47,344,490T/Cuncertain significance
rs7672890757:47,344,491G/Tuncertain significance
rs7586908267:47,344,520C/Auncertain significance
rs7519556317:47,344,521G/Auncertain significance
rs12238030127:47,344,542C/Tuncertain significance
rs3681950557:47,344,593T/Clikely benign
rs78095977:47,375,200C/A
rs3692590697:47,384,364T/Cuncertain significance
rs2018021917:47,384,395G/Tuncertain significance
rs1402414257:47,384,400G/Abenign
rs617313107:47,384,411C/Tbenign
rs5671207997:47,384,422G/Auncertain significance
rs617313117:47,384,614T/Cuncertain significance
rs25470348657:47,384,636T/Cuncertain significance
rs1898384927:47,384,646G/Abenign
rs7583126827:47,385,790T/Guncertain significance
rs2016496837:47,385,793C/Tuncertain significance
rs2019412337:47,385,798G/Auncertain significance
rs5628168347:47,385,816G/Auncertain significance
rs25470423757:47,385,861T/Cuncertain significance
rs3693050837:47,385,893G/Cuncertain significance
rs10306759847:47,385,909C/Tuncertain significance
rs17893419087:47,385,941T/Glikely benign
rs13288154747:47,407,990C/Guncertain significance
rs10125525637:47,408,012C/Tuncertain significance
rs7774011897:47,408,022G/Auncertain significance
rs1999388917:47,408,073C/Tuncertain significance
rs3679611927:47,408,079C/Tlikely benign
rs7555924957:47,408,085T/Cuncertain significance
rs7786453947:47,408,112G/Cuncertain significance
rs3752738597:47,408,148T/Auncertain significance
rs78086467:47,408,208C/Tbenign
rs1421751607:47,408,209G/Alikely benign
rs1144883717:47,408,252G/Abenign
rs5420600797:47,408,286G/Tuncertain significance
rs10304441167:47,408,331T/Cuncertain significance
rs7659398207:47,408,355G/Auncertain significance
rs7585926047:47,408,381C/Tuncertain significance
rs5629950797:47,408,409C/Tuncertain significance
rs3675562547:47,408,414C/Tuncertain significance
rs12311454627:47,408,425A/Tuncertain significance
rs733265327:47,408,426T/Cbenign
rs5613892707:47,408,433C/Tuncertain significance
rs7530832887:47,408,524G/Alikely benign
rs17908862577:47,408,597T/Cuncertain significance
rs3754209687:47,408,605G/Alikely benign
rs3760583707:47,408,627G/Auncertain significance
rs5520813577:47,408,645G/Auncertain significance
rs1397819987:47,408,718G/Alikely benign
rs7766634027:47,408,735T/Glikely benign
rs9497578717:47,408,753G/Auncertain significance
rs1430623027:47,408,782C/Tlikely benign
rs7471300337:47,408,802C/Tuncertain significance
rs7641456457:47,408,826G/Auncertain significance
rs7615499947:47,408,884C/Tlikely benign
rs2009063907:47,408,900C/Tuncertain significance
rs15844997067:47,408,902A/Glikely benign
rs25471707147:47,409,042T/Cuncertain significance

Showing 100 of 136 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.