TRAF3

TNF receptor associated factor 3

Summary

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]

Known Variants341 total

rsidPosition (GRCh37)AllelesClassClinVar
rs105175014:103,243,946C/A——
rs1288752114:103,247,844C/Aintron variant—
rs14803379214:103,259,975T/Cupstream gene variant—
rs714528414:103,264,323C/Tintron variant—
rs1214725414:103,265,666G/C——
rs1214724614:103,265,844A/Gintron variant—
rs399334714:103,267,403T/Cintron variant—
rs3591928214:103,268,411G/Tintron variant—
rs53980840714:103,272,939G/A——
rs1287853214:103,279,795C/G——
rs1243439614:103,282,602C/A——
rs2848307014:103,292,110T/Cintron variant—
rs56788865414:103,293,290T/C——
rs714658114:103,301,072C/A——
rs15028254114:103,307,295A/Gintron variant—
rs14434656514:103,309,616A/Gintron variant—
rs801794414:103,320,048T/A——
rs801326614:103,326,780T/Cintron variant—
rs967169414:103,330,144C/T——
rs657593214:103,330,609T/Cupstream gene variant—
rs715890114:103,333,229C/Gdownstream gene variant—
rs254242993214:103,336,545T/C—uncertain significance
rs37742751714:103,336,547G/C—likely benign
rs129208479814:103,336,554A/G—uncertain significance
rs254243012514:103,336,563T/A—uncertain significance
rs130217023914:103,336,566C/A—uncertain significance
rs54249429414:103,336,567C/T—uncertain significance
rs13912724214:103,336,572G/A—conflicting classifications of pathogenicity
rs74648355914:103,336,573C/T—uncertain significance
rs19963933914:103,336,574G/A—likely benign
rs101380203014:103,336,580G/C—uncertain significance
rs74551764314:103,336,588C/T—uncertain significance
rs116612104914:103,336,589G/A—likely benign
rs14545607714:103,336,591C/G—uncertain significance
rs77519733214:103,336,592G/A—likely benign
rs76282771514:103,336,595A/G—likely benign
rs101940963314:103,336,605A/G—uncertain significance
rs129392322914:103,336,611C/T—uncertain significance
rs37095520514:103,336,612G/A—uncertain significance
rs37554596414:103,336,614A/C—uncertain significance
rs75977220714:103,336,617G/C—uncertain significance
rs54718044514:103,336,624C/T—uncertain significance
rs122272365714:103,336,625G/A—likely benign
rs254243063914:103,336,628A/G—likely benign
rs138899933014:103,336,649A/G—likely benign
rs76471545214:103,336,656A/G—uncertain significance
rs254243078314:103,336,662A/G—uncertain significance
rs75198034314:103,336,664G/C—uncertain significance
rs20141548314:103,336,676C/T—likely benign
rs75572196314:103,336,677G/A—uncertain significance
rs116534614114:103,336,691C/T—likely benign
rs77984499014:103,336,694G/T—uncertain significance
rs155537388514:103,336,703G/A—likely benign
rs18344355814:103,336,723G/A—conflicting classifications of pathogenicity
rs188826723514:103,336,726C/T—uncertain significance
rs14235052714:103,336,727G/A—benign
rs127543598914:103,336,736C/G—likely benign
rs156678615514:103,336,737G/A—uncertain significance
rs77678254014:103,336,748C/T—likely benign
rs188826933814:103,336,750G/A—uncertain significance
rs75987181014:103,336,757C/T—likely benign
rs77555658814:103,336,771C/T—uncertain significance
rs36880723414:103,336,789C/T—uncertain significance
rs54997185314:103,336,790G/A—likely benign
rs76704291114:103,336,794T/A—likely benign
rs93505599114:103,336,795C/T—likely benign
rs140268479314:103,336,797C/T—likely benign
rs20059217914:103,336,799C/T—benign
rs77972197114:103,336,800G/T—likely benign
rs19144720714:103,336,802C/T—benign
rs2867097014:103,336,804C/T—benign
rs11702691714:103,336,841C/Gdownstream gene variant—
rs75451798514:103,338,236A/G—likely benign
rs188836222514:103,338,237C/T—likely benign
rs103316925714:103,338,240G/T—likely benign
rs14643545514:103,338,254C/G—uncertain significance
rs77790112414:103,338,261A/G—uncertain significance
rs213983579914:103,338,268A/C—uncertain significance
rs14787114514:103,338,275A/C—likely benign
rs92860960914:103,338,277C/T—uncertain significance
rs14901892814:103,338,278G/A—likely benign
rs188836563714:103,338,293C/T—likely benign
rs91332581314:103,338,303A/G—uncertain significance
rs74953278514:103,338,315G/A—likely benign
rs94515060014:103,338,316G/T—likely benign
rs18481272014:103,338,317T/G—benign
rs229540214:103,338,324T/A—benign
rs144888241914:103,341,963G/A—likely benign
rs120252741814:103,341,978C/T—likely benign
rs254245156414:103,341,981C/T—likely benign
rs254245168614:103,342,008C/A—likely benign
rs37237011414:103,342,010A/G—uncertain significance
rs14381318914:103,342,015C/T—conflicting classifications of pathogenicity
rs74937392314:103,342,016G/A—uncertain significance
rs213985335114:103,342,028G/C—uncertain significance
rs254245174714:103,342,033T/G—uncertain significance
rs132757344214:103,342,038A/C—likely benign
rs113187714:103,342,049T/Cmissense variantbenign
rs77349782214:103,342,053G/A—likely benign
rs124729131614:103,342,054G/C—uncertain significance

Showing 100 of 341 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.