TRAF7

TNF receptor associated factor 7

Summary

Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]

Known Variants119 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs2093067299	16:2,213,922	A/G	—	uncertain significance
rs2093067316	16:2,213,935	A/G	—	uncertain significance
rs748444237	16:2,213,936	G/C	—	likely benign
rs770881335	16:2,213,952	C/T	—	likely benign
rs759408599	16:2,213,953	G/A	—	likely benign
rs766923754	16:2,213,977	T/C	—	uncertain significance
rs749890921	16:2,213,986	C/A	—	uncertain significance
rs746647663	16:2,215,907	G/A	—	likely benign
rs774893357	16:2,215,919	G/A	—	uncertain significance
rs750759264	16:2,215,933	A/G	—	likely benign
rs377419205	16:2,215,943	C/T	—	likely benign
rs200141222	16:2,218,090	G/A	—	likely benign
rs2141279710	16:2,218,097	C/A	—	uncertain significance
rs1567249641	16:2,218,116	C/T	—	uncertain significance
rs369733800	16:2,218,138	C/G	—	likely benign
rs765305848	16:2,218,143	T/C	—	uncertain significance
rs759262381	16:2,220,627	A/G	—	uncertain significance
rs2545002470	16:2,220,631	C/T	—	uncertain significance
rs200035101	16:2,220,647	C/T	—	likely benign
rs1226377975	16:2,220,651	A/G	—	uncertain significance
rs372494731	16:2,221,274	G/A	—	uncertain significance
rs762161563	16:2,221,578	G/A	—	likely benign
rs34752687	16:2,221,593	C/T	—	benign
rs143997074	16:2,221,596	C/T	—	likely benign
rs144871289	16:2,221,599	G/C	—	likely benign
rs2545004884	16:2,222,193	G/C	—	uncertain significance
rs751318317	16:2,222,203	G/A	—	uncertain significance
rs2545004945	16:2,222,227	G/C	—	uncertain significance
rs371460998	16:2,222,262	G/A	—	likely benign
rs761486543	16:2,222,300	C/T	—	uncertain significance
rs35765267	16:2,222,307	C/T	—	likely benign
rs141784925	16:2,222,343	G/A	—	likely benign
rs769966564	16:2,222,358	C/G	—	uncertain significance
rs749350622	16:2,222,367	C/G	—	uncertain significance
rs768623972	16:2,222,368	G/T	—	uncertain significance
rs760492852	16:2,222,493	G/C	—	uncertain significance
rs757728472	16:2,222,528	C/T	—	likely benign
rs564325600	16:2,222,529	G/A	—	likely benign
rs750793648	16:2,222,533	C/G	—	likely benign
rs2545005548	16:2,222,594	A/C	—	uncertain significance
rs187643207	16:2,222,598	T/C	—	benign
rs373051088	16:2,223,188	C/T	—	uncertain significance
rs560235497	16:2,223,195	C/T	—	likely benign
rs373436400	16:2,223,213	C/T	—	likely benign
rs2545006425	16:2,223,223	C/G	—	uncertain significance
rs762428798	16:2,223,230	C/A	—	uncertain significance
rs2545006497	16:2,223,268	A/G	—	uncertain significance
rs745725943	16:2,223,277	C/T	—	uncertain significance
rs369566946	16:2,223,285	C/A	—	uncertain significance
rs138752269	16:2,223,306	C/G	—	likely benign
rs757410464	16:2,223,334	C/T	—	uncertain significance
rs377382568	16:2,223,357	G/A	—	likely benign
rs371429918	16:2,223,362	A/G	—	uncertain significance
rs2545006778	16:2,223,477	C/G	—	uncertain significance
rs201641425	16:2,223,483	C/T	—	conflicting classifications of pathogenicity
rs1567252467	16:2,223,505	A/G	—	pathogenic
rs2093122295	16:2,223,532	C/T	—	uncertain significance
rs942789564	16:2,223,541	G/A	—	uncertain significance
rs368139413	16:2,223,791	C/A	—	uncertain significance
rs1567252659	16:2,223,813	C/G	—	pathogenic
rs1567252663	16:2,223,814	G/A	—	conflicting classifications of pathogenicity
rs2545007299	16:2,223,818	G/C	—	likely benign
rs2545007312	16:2,223,826	G/A	—	likely pathogenic
rs2141290647	16:2,223,844	A/G	—	uncertain significance
rs184394516	16:2,223,855	G/A	—	benign
rs199630186	16:2,223,877	C/G	—	likely benign
rs2545007631	16:2,223,934	A/C	—	uncertain significance
rs2141291233	16:2,223,990	C/G	—	pathogenic
rs138647853	16:2,223,995	C/T	—	likely benign
rs200505184	16:2,223,996	G/T	—	uncertain significance
rs2093126233	16:2,224,261	A/T	—	likely pathogenic
rs765386143	16:2,224,276	A/G	—	conflicting classifications of pathogenicity
rs918826424	16:2,224,297	G/A	—	uncertain significance
rs2545008142	16:2,224,302	T/C	—	likely benign
rs2545008173	16:2,224,319	C/T	—	uncertain significance
rs2545008190	16:2,224,327	A/C	—	uncertain significance
rs769282968	16:2,224,337	G/A	—	uncertain significance
rs2093130178	16:2,225,111	G/C	—	uncertain significance
rs2093130231	16:2,225,130	C/G	—	likely benign
rs377479113	16:2,225,142	C/T	—	likely benign
rs537605138	16:2,225,360	T/C	—	uncertain significance
rs557570814	16:2,225,379	A/C	—	likely benign
rs1280990910	16:2,225,383	A/C	—	uncertain significance
rs139483392	16:2,225,386	G/A	—	likely benign
rs1596680065	16:2,225,507	G/C	—	uncertain significance
rs763780388	16:2,225,564	G/T	—	uncertain significance
rs2093132159	16:2,225,567	C/T	—	pathogenic
rs200042334	16:2,225,602	C/T	—	likely benign
rs2141295415	16:2,225,611	C/A	—	uncertain significance
rs145525624	16:2,225,614	G/A	—	benign
rs2141295475	16:2,225,618	A/G	—	uncertain significance
rs150545244	16:2,225,673	C/A	downstream gene variant	—
rs1308958696	16:2,225,847	C/T	—	uncertain significance
rs781270559	16:2,225,848	G/A	—	uncertain significance
rs2141297041	16:2,225,859	T/C	—	uncertain significance
rs749613683	16:2,225,868	G/A	—	uncertain significance
rs117821778	16:2,225,876	G/A	—	likely benign
rs2141297268	16:2,225,881	C/T	—	pathogenic
rs1421625187	16:2,225,923	T/C	—	uncertain significance
rs2141297841	16:2,225,946	C/T	—	uncertain significance

Showing 100 of 119 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.