rs187643207

This variant is located in the TRAF7 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

diastolic blood pressure

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele T

OR 0.36

p 2.0e-12

N 1,028,980

Large GWAS

multi-ancestry

systolic blood pressure

Allele T

OR 0.49

p 2.0e-9

N 1,028,980

Large GWAS

multi-ancestry

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ClinVar annotation

Benign★★★☆

4 submitters2 publications

not provided; TRAF7-related disorder; Colon adenocarcinoma; Adrenocortical carcinoma, hereditary; Cervical cancer; Glioma susceptibility 1; Gastric cancer; Ovarian serous cystadenocarcinoma; Hepatocellular carcinoma; Clear cell carcinoma of kidney; Sarcoma; Malignant tumor of esophagus; Lung cancer

View on ClinVar →

About TRAF7

Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]