TRAIP

TRAF interacting protein

Summary

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]

Known Variants138 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1128535	3:49,866,392	C/T	3 prime UTR variant	benign
rs146951959	3:49,866,539	C/T	—	likely benign
rs2544951952	3:49,866,543	C/A	—	uncertain significance
rs747364226	3:49,866,552	G/T	—	uncertain significance
rs35129566	3:49,866,584	T/G	—	benign
rs144112402	3:49,866,602	C/A	—	uncertain significance
rs2081709328	3:49,866,611	C/T	—	likely benign
rs924201547	3:49,866,629	A/G	—	likely benign
rs149640331	3:49,866,630	G/C	—	uncertain significance
rs148292576	3:49,866,639	C/T	—	uncertain significance
rs536675100	3:49,866,640	G/A	—	uncertain significance
rs375819762	3:49,866,649	C/T	—	uncertain significance
rs982881853	3:49,866,654	T/C	—	uncertain significance
rs146485772	3:49,866,662	G/A	—	likely benign
rs377703753	3:49,866,667	G/A	—	benign
rs1167939360	3:49,866,672	C/T	—	likely benign
rs370712427	3:49,866,881	A/G	—	likely benign
rs146306196	3:49,866,894	C/A	—	uncertain significance
rs143716103	3:49,866,909	C/G	—	benign
rs142854364	3:49,866,910	C/T	—	uncertain significance
rs756563521	3:49,866,917	C/T	—	uncertain significance
rs778129131	3:49,866,918	G/A	—	likely benign
rs771177157	3:49,866,930	G/A	—	likely benign
rs774388594	3:49,866,936	C/T	—	likely benign
rs1478352918	3:49,866,961	T/C	—	likely benign
rs2544952808	3:49,867,040	C/T	—	likely benign
rs747802071	3:49,867,066	G/A	—	uncertain significance
rs2544952878	3:49,867,080	G/C	—	likely benign
rs778074273	3:49,867,091	G/A	—	uncertain significance
rs746923103	3:49,867,128	A/G	—	likely benign
rs1559444250	3:49,867,151	C/A	—	uncertain significance
rs761742550	3:49,867,193	G/A	—	likely pathogenic
rs747944433	3:49,867,436	T/C	—	likely benign
rs374301425	3:49,867,445	G/C	—	likely benign
rs145654028	3:49,867,472	A/G	—	likely benign
rs754282137	3:49,867,483	G/A	—	likely benign
rs2544953458	3:49,867,495	T/C	—	likely benign
rs535151842	3:49,867,508	G/A	—	likely benign
rs695238	3:49,869,158	C/A	—	benign
rs759198190	3:49,869,338	C/T	—	likely benign
rs2544955305	3:49,869,354	C/T	—	likely benign
rs763295325	3:49,869,368	G/A	—	uncertain significance
rs766612476	3:49,869,374	C/T	—	likely benign
rs751675538	3:49,869,375	G/A	—	likely benign
rs144992965	3:49,869,382	C/A	—	likely benign
rs777634395	3:49,869,397	G/A	—	uncertain significance
rs1381084072	3:49,869,412	G/A	—	uncertain significance
rs376933772	3:49,869,441	A/G	—	likely benign
rs201338202	3:49,869,454	C/T	—	uncertain significance
rs138957781	3:49,869,455	G/A	—	uncertain significance
rs1419872467	3:49,869,462	T/C	—	likely benign
rs143310707	3:49,869,488	C/T	—	conflicting classifications of pathogenicity
rs1241235933	3:49,869,494	G/A	—	uncertain significance
rs776210241	3:49,869,518	C/G	—	likely benign
rs13085679	3:49,869,631	G/A	—	benign
rs4519692	3:49,873,188	C/T	intron variant	—
rs149800672	3:49,877,220	C/T	—	uncertain significance
rs201373472	3:49,877,221	G/A	—	uncertain significance
rs377353118	3:49,877,225	G/A	—	likely benign
rs762017803	3:49,877,273	C/T	—	likely benign
rs1473208611	3:49,877,295	T/C	—	likely pathogenic
rs751394626	3:49,877,302	G/A	—	likely benign
rs780942289	3:49,877,308	G/A	—	likely benign
rs9858428	3:49,877,585	G/T	—	benign
rs749187812	3:49,877,719	T/C	—	uncertain significance
rs2544966060	3:49,877,751	T/A	—	uncertain significance
rs371198808	3:49,877,768	T/C	—	likely benign
rs373674729	3:49,877,782	C/G	—	uncertain significance
rs1181147452	3:49,877,787	T/G	—	uncertain significance
rs2081828234	3:49,877,788	C/A	—	pathogenic
rs780676622	3:49,877,809	A/G	—	uncertain significance
rs886797478	3:49,877,820	T/C	—	likely benign
rs2271960	3:49,878,078	T/C	—	benign
rs1996663	3:49,878,264	C/G	—	benign
rs1996664	3:49,878,395	A/G	—	benign
rs1278076514	3:49,878,428	G/A	—	uncertain significance
rs756300840	3:49,878,498	C/T	—	uncertain significance
rs529438671	3:49,878,499	G/A	—	likely benign
rs749360609	3:49,878,508	G/T	—	uncertain significance
rs1229723858	3:49,878,515	G/A	—	likely benign
rs6776029	3:49,878,590	T/C	—	benign
rs1317140	3:49,878,652	G/A	—	benign
rs75160702	3:49,878,779	C/G	—	—
rs939376	3:49,879,202	C/T	—	benign
rs1486715969	3:49,879,255	G/A	—	uncertain significance
rs531391341	3:49,879,273	A/G	—	likely benign
rs774388805	3:49,879,297	C/T	—	likely benign
rs767664526	3:49,879,323	G/A	stop gained	pathogenic
rs139724116	3:49,879,341	C/T	—	uncertain significance
rs1318543714	3:49,879,347	G/A	—	uncertain significance
rs2544968585	3:49,879,363	A/C	—	likely benign
rs1421268670	3:49,879,385	C/T	—	likely benign
rs769472431	3:49,879,874	C/T	—	likely benign
rs147562021	3:49,879,917	G/A	—	uncertain significance
rs143366962	3:49,879,919	C/T	—	likely benign
rs2081848600	3:49,879,985	A/C	—	uncertain significance
rs773832747	3:49,879,986	G/A	—	likely benign
rs2246832	3:49,881,134	A/T	—	benign
rs767442984	3:49,881,257	C/T	—	uncertain significance
rs758078842	3:49,881,297	A/G	—	likely benign

Showing 100 of 138 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.