TREML2
triggering receptor expressed on myeloid cells like 2
Summary
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]
Known Variants32 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7754593 | 6:41,159,222 | G/T | 3 prime UTR variant | — |
| rs9394767 | 6:41,159,905 | A/G | 3 prime UTR variant | — |
| rs145034109 | 6:41,160,187 | T/C | — | uncertain significance |
| rs562393290 | 6:41,160,215 | G/A | — | uncertain significance |
| rs770747457 | 6:41,160,573 | C/T | — | uncertain significance |
| rs774938098 | 6:41,160,619 | G/C | — | uncertain significance |
| rs13216201 | 6:41,162,060 | G/T | intron variant | — |
| rs773665047 | 6:41,162,165 | G/C | — | uncertain significance |
| rs2532422141 | 6:41,162,179 | A/G | — | likely benign |
| rs185375765 | 6:41,162,197 | G/C | — | uncertain significance |
| rs369023699 | 6:41,162,201 | T/A | — | uncertain significance |
| rs2113904561 | 6:41,162,223 | G/A | — | uncertain significance |
| rs147159415 | 6:41,162,310 | G/A | — | uncertain significance |
| rs780153970 | 6:41,162,328 | C/A | — | uncertain significance |
| rs377165160 | 6:41,162,386 | T/A | — | uncertain significance |
| rs369601224 | 6:41,162,395 | C/T | — | likely benign |
| rs3747742 | 6:41,162,518 | T/C | missense variant | — |
| rs759022688 | 6:41,162,530 | T/C | — | uncertain significance |
| rs374114737 | 6:41,162,541 | G/A | — | uncertain significance |
| rs6915083 | 6:41,164,005 | A/T | — | — |
| rs140974034 | 6:41,165,877 | A/G | — | likely benign |
| rs1315593731 | 6:41,165,897 | G/C | — | likely benign |
| rs371918667 | 6:41,165,996 | C/T | — | uncertain significance |
| rs555770440 | 6:41,166,031 | C/G | — | uncertain significance |
| rs745667653 | 6:41,166,086 | T/C | — | uncertain significance |
| rs780349398 | 6:41,166,090 | C/T | — | likely benign |
| rs1342180774 | 6:41,166,104 | T/C | — | uncertain significance |
| rs62396355 | 6:41,166,149 | A/G | missense variant | — |
| rs61998254 | 6:41,166,151 | A/G | synonymous variant | — |
| rs77704965 | 6:41,166,154 | G/C | — | benign |
| rs4714431 | 6:41,168,337 | A/T | — | — |
| rs1766262189 | 6:41,168,705 | C/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.