TRIM5
tripartite motif containing 5
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]
Known Variants52 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7108470 | 11:5,625,603 | A/G | intron variant | — |
| rs7947253 | 11:5,674,088 | T/C | intergenic variant | — |
| rs7119739 | 11:5,677,685 | G/C | — | — |
| rs755157567 | 11:5,681,852 | C/T | — | — |
| rs7122620 | 11:5,683,567 | G/A | downstream gene variant | — |
| rs1976339 | 11:5,684,402 | C/T | — | — |
| rs7104422 | 11:5,686,085 | G/A | — | benign |
| rs149864129 | 11:5,686,136 | T/C | — | uncertain significance |
| rs775532503 | 11:5,686,163 | T/C | — | uncertain significance |
| rs758747919 | 11:5,686,211 | C/T | — | uncertain significance |
| rs148933048 | 11:5,686,213 | A/C | — | uncertain significance |
| rs755466873 | 11:5,686,274 | C/G | — | uncertain significance |
| rs553273809 | 11:5,686,394 | C/T | — | likely benign |
| rs1851033460 | 11:5,686,400 | C/T | — | uncertain significance |
| rs2494112150 | 11:5,686,466 | T/C | — | uncertain significance |
| rs375450398 | 11:5,686,467 | G/C | — | uncertain significance |
| rs1323234902 | 11:5,686,481 | C/T | — | uncertain significance |
| rs781036391 | 11:5,686,506 | A/T | — | uncertain significance |
| rs765919035 | 11:5,686,547 | G/T | — | uncertain significance |
| rs1851052089 | 11:5,686,599 | T/C | — | uncertain significance |
| rs1338700202 | 11:5,686,614 | C/A | — | likely benign |
| rs1293356308 | 11:5,687,231 | C/T | — | uncertain significance |
| rs752893614 | 11:5,687,258 | C/G | — | uncertain significance |
| rs11820502 | 11:5,688,024 | G/C | intron variant | — |
| rs58270597 | 11:5,688,683 | C/T | intron variant | — |
| rs760714681 | 11:5,688,929 | C/T | — | likely benign |
| rs55868421 | 11:5,688,948 | G/A | — | benign |
| rs12271225 | 11:5,690,544 | A/G | — | — |
| rs58200149 | 11:5,692,144 | G/A | intron variant | — |
| rs56334873 | 11:5,692,825 | C/T | intron variant | — |
| rs55652931 | 11:5,692,838 | A/T | intron variant | — |
| rs2880345 | 11:5,693,547 | G/T | intron variant | — |
| rs12806645 | 11:5,698,455 | G/A | — | — |
| rs116744384 | 11:5,699,424 | C/T | — | benign |
| rs1368628151 | 11:5,699,451 | C/T | — | likely benign |
| rs577964412 | 11:5,699,465 | C/T | — | uncertain significance |
| rs58187248 | 11:5,699,491 | T/C | — | benign |
| rs774429176 | 11:5,699,510 | T/A | — | uncertain significance |
| rs140632799 | 11:5,699,528 | G/C | — | uncertain significance |
| rs2494264090 | 11:5,699,584 | A/T | — | likely benign |
| rs780254989 | 11:5,699,637 | C/T | — | likely benign |
| rs553729821 | 11:5,700,309 | A/G | — | uncertain significance |
| rs10838525 | 11:5,701,001 | C/T | missense variant | — |
| rs143587466 | 11:5,701,008 | C/T | — | uncertain significance |
| rs749087471 | 11:5,701,124 | C/G | — | uncertain significance |
| rs367852068 | 11:5,701,196 | C/T | — | uncertain significance |
| rs148583858 | 11:5,701,197 | G/A | — | uncertain significance |
| rs757043585 | 11:5,701,233 | G/A | — | uncertain significance |
| rs768816295 | 11:5,701,261 | G/T | — | uncertain significance |
| rs1328783249 | 11:5,701,271 | G/A | — | uncertain significance |
| rs3740996 | 11:5,701,281 | G/A | missense variant | — |
| rs148345924 | 11:5,878,609 | G/C | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.