TTC3
tetratricopeptide repeat domain 3
Summary
Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants145 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs768633670 | 21:38,444,814 | A/G | missense variant | pathogenic |
| rs1155786 | 21:38,448,025 | A/G | upstream gene variant | — |
| rs773160877 | 21:38,459,577 | G/A | — | uncertain significance |
| rs1281526371 | 21:38,459,616 | G/A | — | uncertain significance |
| rs141884251 | 21:38,459,619 | C/G | — | uncertain significance |
| rs930252432 | 21:38,459,632 | T/C | — | likely benign |
| rs2072716935 | 21:38,460,173 | T/C | — | uncertain significance |
| rs772950107 | 21:38,460,513 | A/G | — | uncertain significance |
| rs556511744 | 21:38,460,535 | C/T | — | uncertain significance |
| rs767070391 | 21:38,460,622 | G/A | — | uncertain significance |
| rs1279584091 | 21:38,460,634 | G/A | — | uncertain significance |
| rs750841426 | 21:38,460,642 | G/A | — | uncertain significance |
| rs2073076999 | 21:38,462,549 | T/C | — | uncertain significance |
| rs145091703 | 21:38,463,641 | G/A | — | uncertain significance |
| rs2516884732 | 21:38,463,665 | G/A | — | uncertain significance |
| rs1376639975 | 21:38,463,669 | C/T | — | uncertain significance |
| rs3753070 | 21:38,466,261 | T/A | intron variant | — |
| rs143762501 | 21:38,467,644 | T/C | — | benign |
| rs562162962 | 21:38,467,692 | A/G | — | uncertain significance |
| rs201483714 | 21:38,467,720 | A/G | — | uncertain significance |
| rs186310557 | 21:38,468,928 | G/C | — | uncertain significance |
| rs1003719 | 21:38,491,095 | A/T | — | — |
| rs2517057427 | 21:38,494,165 | T/C | — | uncertain significance |
| rs2517057465 | 21:38,494,169 | C/T | — | uncertain significance |
| rs997638652 | 21:38,494,204 | A/G | — | uncertain significance |
| rs2517067587 | 21:38,495,301 | A/G | — | uncertain significance |
| rs2835610 | 21:38,495,849 | A/G | intron variant | — |
| rs772508970 | 21:38,496,936 | G/A | — | likely benign |
| rs148546407 | 21:38,496,953 | T/C | — | uncertain significance |
| rs777833962 | 21:38,497,022 | G/A | — | uncertain significance |
| rs150729070 | 21:38,498,418 | T/C | — | benign |
| rs137980463 | 21:38,501,355 | A/G | — | benign |
| rs777391460 | 21:38,504,984 | C/T | — | uncertain significance |
| rs2517158201 | 21:38,505,056 | C/G | — | uncertain significance |
| rs2077580549 | 21:38,505,059 | C/T | — | uncertain significance |
| rs143083365 | 21:38,507,692 | A/G | — | uncertain significance |
| rs954958487 | 21:38,507,702 | T/C | — | uncertain significance |
| rs774751265 | 21:38,507,749 | C/T | — | uncertain significance |
| rs759788587 | 21:38,507,755 | C/T | — | uncertain significance |
| rs765922585 | 21:38,507,809 | A/G | — | uncertain significance |
| rs2835621 | 21:38,510,616 | G/A | intron variant | — |
| rs376677379 | 21:38,512,868 | C/G | — | uncertain significance |
| rs200911343 | 21:38,516,841 | A/C | — | uncertain significance |
| rs139364689 | 21:38,516,874 | C/T | — | uncertain significance |
| rs149998163 | 21:38,516,892 | A/G | — | uncertain significance |
| rs2517254022 | 21:38,516,934 | C/G | — | likely benign |
| rs139582379 | 21:38,516,936 | A/G | — | benign |
| rs372074813 | 21:38,516,939 | A/T | — | uncertain significance |
| rs2517270877 | 21:38,519,808 | T/C | — | uncertain significance |
| rs147844068 | 21:38,519,831 | T/G | — | uncertain significance |
| rs747475282 | 21:38,520,855 | C/T | — | uncertain significance |
| rs762235627 | 21:38,520,862 | G/C | — | uncertain significance |
| rs1305456430 | 21:38,520,872 | G/C | — | uncertain significance |
| rs2835630 | 21:38,521,842 | A/G | regulatory region variant | — |
| rs1192853400 | 21:38,522,378 | G/A | — | uncertain significance |
| rs1378053332 | 21:38,522,385 | T/C | — | uncertain significance |
| rs374540924 | 21:38,522,403 | C/T | — | uncertain significance |
| rs2079329019 | 21:38,522,414 | G/A | — | uncertain significance |
| rs965698889 | 21:38,522,438 | A/G | — | uncertain significance |
| rs776528086 | 21:38,523,145 | A/C | — | uncertain significance |
| rs2517292277 | 21:38,523,157 | G/T | — | uncertain significance |
| rs2079505327 | 21:38,524,213 | A/G | — | uncertain significance |
| rs372384613 | 21:38,524,230 | A/G | — | uncertain significance |
| rs145296151 | 21:38,525,268 | C/G | — | uncertain significance |
| rs749136748 | 21:38,525,272 | G/A | — | likely benign |
| rs2517309553 | 21:38,525,373 | C/T | — | uncertain significance |
| rs370229430 | 21:38,525,416 | T/C | — | uncertain significance |
| rs56032400 | 21:38,525,444 | A/G | — | benign |
| rs2517310978 | 21:38,525,575 | T/G | — | uncertain significance |
| rs150636284 | 21:38,528,970 | A/G | — | benign |
| rs2517338583 | 21:38,529,096 | C/A | — | uncertain significance |
| rs2517339347 | 21:38,529,202 | A/G | — | uncertain significance |
| rs202179827 | 21:38,533,118 | G/C | — | uncertain significance |
| rs1259593894 | 21:38,536,450 | G/A | — | uncertain significance |
| rs770766827 | 21:38,536,463 | G/T | — | uncertain significance |
| rs767194001 | 21:38,536,471 | A/G | — | uncertain significance |
| rs1204419590 | 21:38,536,502 | G/T | — | uncertain significance |
| rs2517397069 | 21:38,537,863 | A/G | — | uncertain significance |
| rs1390644418 | 21:38,537,883 | C/T | — | uncertain significance |
| rs367772253 | 21:38,537,920 | A/G | — | uncertain significance |
| rs200198693 | 21:38,538,037 | T/C | — | uncertain significance |
| rs183602088 | 21:38,538,144 | G/T | — | uncertain significance |
| rs986747182 | 21:38,538,151 | G/A | — | uncertain significance |
| rs140734031 | 21:38,538,243 | A/G | — | likely benign |
| rs754928051 | 21:38,538,282 | C/T | — | uncertain significance |
| rs376759575 | 21:38,538,309 | G/T | — | uncertain significance |
| rs61998236 | 21:38,538,319 | A/G | — | benign |
| rs1342302207 | 21:38,538,345 | A/C | — | uncertain significance |
| rs755983805 | 21:38,538,409 | C/G | — | uncertain significance |
| rs139841428 | 21:38,538,417 | G/C | — | uncertain significance |
| rs141847812 | 21:38,538,423 | G/T | — | uncertain significance |
| rs2517399770 | 21:38,538,441 | G/T | — | uncertain significance |
| rs1601924362 | 21:38,538,446 | A/G | — | likely benign |
| rs190784117 | 21:38,538,472 | C/T | — | uncertain significance |
| rs1379947240 | 21:38,538,477 | C/A | — | uncertain significance |
| rs139664343 | 21:38,538,530 | G/T | — | benign |
| rs146714367 | 21:38,538,579 | C/T | — | uncertain significance |
| rs144028387 | 21:38,538,641 | C/G | — | uncertain significance |
| rs773106309 | 21:38,538,679 | A/C | — | uncertain significance |
| rs2517400906 | 21:38,538,682 | A/G | — | uncertain significance |
Showing 100 of 145 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.