UBE3D
ubiquitin protein ligase E3D
Summary
Enables cyclin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Involved in protein autoubiquitination; protein monoubiquitination; and protein polyubiquitination. Part of ubiquitin ligase complex. Is active in cytosol. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants37 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs759082824 | 6:83,602,748 | T/G | — | uncertain significance |
| rs62430477 | 6:83,629,612 | C/T | downstream gene variant | — |
| rs12200420 | 6:83,644,095 | T/C | intron variant | — |
| rs293526 | 6:83,648,056 | C/G | coding sequence variant | — |
| rs143403921 | 6:83,667,048 | G/A | — | likely benign |
| rs773185446 | 6:83,667,050 | C/T | — | uncertain significance |
| rs2482198643 | 6:83,667,123 | G/C | — | uncertain significance |
| rs62419171 | 6:83,690,725 | C/T | intron variant | — |
| rs2770675 | 6:83,705,017 | G/A | regulatory region variant | — |
| rs2480091 | 6:83,706,592 | A/C | — | — |
| rs761572341 | 6:83,728,752 | C/A | — | uncertain significance |
| rs150313651 | 6:83,728,759 | C/T | — | uncertain significance |
| rs137922412 | 6:83,728,771 | T/C | — | uncertain significance |
| rs771501277 | 6:83,728,788 | A/T | — | uncertain significance |
| rs1781167123 | 6:83,732,173 | A/C | — | uncertain significance |
| rs548304473 | 6:83,732,276 | A/C | — | uncertain significance |
| rs969475827 | 6:83,732,279 | A/G | — | uncertain significance |
| rs6938070 | 6:83,745,018 | T/G | — | — |
| rs147405452 | 6:83,748,171 | G/A | — | uncertain significance |
| rs1782883427 | 6:83,754,157 | T/C | — | uncertain significance |
| rs2533227766 | 6:83,754,161 | T/G | — | uncertain significance |
| rs765389897 | 6:83,754,178 | C/T | — | uncertain significance |
| rs780419827 | 6:83,754,297 | A/C | — | uncertain significance |
| rs753813517 | 6:83,754,362 | G/A | — | uncertain significance |
| rs1464349964 | 6:83,763,870 | T/G | — | uncertain significance |
| rs149767269 | 6:83,763,871 | C/T | — | uncertain significance |
| rs900436468 | 6:83,763,880 | T/G | — | uncertain significance |
| rs1783912388 | 6:83,767,595 | A/G | — | likely benign |
| rs771453519 | 6:83,767,613 | C/T | — | uncertain significance |
| rs2533338438 | 6:83,767,647 | G/A | — | uncertain significance |
| rs2533338458 | 6:83,767,650 | G/A | — | uncertain significance |
| rs1442775013 | 6:83,767,665 | A/C | — | uncertain significance |
| rs1275653050 | 6:83,767,725 | C/T | — | uncertain significance |
| rs372665243 | 6:83,767,733 | T/C | — | uncertain significance |
| rs375701422 | 6:83,767,736 | G/A | — | uncertain significance |
| rs1405998601 | 6:83,775,388 | T/C | — | likely benign |
| rs200020123 | 6:83,775,392 | C/T | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.