rs293526

This is a coding sequence variant variant in the UBE3D gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Crohn's disease

Jung ES et al. “HLA-C*01 is a Risk Factor for Crohn's Disease.” Inflammatory Bowel Diseases 22(4):796-806 (2016)

Allele T

OR 2.13

p 2.0e-11

N 2,644

Large GWAS

East Asian

About UBE3D

Enables cyclin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Involved in protein autoubiquitination; protein monoubiquitination; and protein polyubiquitination. Part of ubiquitin ligase complex. Is active in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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