UNC5C
unc-5 netrin receptor C
Summary
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]
Known Variants89 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs765338334 | 4:96,090,390 | A/G | — | uncertain significance |
| rs2530400589 | 4:96,090,392 | T/C | — | uncertain significance |
| rs371625546 | 4:96,090,409 | G/A | — | likely benign |
| rs187902349 | 4:96,090,472 | A/G | — | benign |
| rs777195597 | 4:96,090,474 | C/T | — | uncertain significance |
| rs2530400997 | 4:96,090,493 | C/G | — | uncertain significance |
| rs2530401034 | 4:96,090,505 | G/C | — | uncertain significance |
| rs142912978 | 4:96,090,511 | G/A | — | benign |
| rs946762918 | 4:96,091,348 | C/T | — | uncertain significance |
| rs201959747 | 4:96,091,353 | G/A | — | uncertain significance |
| rs773288996 | 4:96,091,357 | G/T | — | uncertain significance |
| rs929930790 | 4:96,091,398 | A/G | — | uncertain significance |
| rs754442812 | 4:96,091,401 | G/A | — | uncertain significance |
| rs34585936 | 4:96,091,414 | C/T | — | benign |
| rs146932015 | 4:96,091,421 | C/T | — | likely benign |
| rs761855500 | 4:96,091,468 | C/T | — | uncertain significance |
| rs150900256 | 4:96,091,473 | C/T | — | uncertain significance |
| rs773054467 | 4:96,091,483 | C/G | — | uncertain significance |
| rs182876652 | 4:96,104,051 | T/C | — | likely benign |
| rs139372477 | 4:96,104,056 | C/T | — | uncertain significance |
| rs145013421 | 4:96,104,057 | G/A | — | likely benign |
| rs144306140 | 4:96,104,065 | T/G | — | uncertain significance |
| rs927398355 | 4:96,104,083 | C/T | — | uncertain significance |
| rs2530436888 | 4:96,104,098 | G/C | — | uncertain significance |
| rs2530436938 | 4:96,104,110 | G/A | — | uncertain significance |
| rs201410096 | 4:96,104,111 | T/A | — | uncertain significance |
| rs2530437369 | 4:96,104,187 | C/T | — | uncertain significance |
| rs933309029 | 4:96,106,219 | G/C | — | uncertain significance |
| rs139502011 | 4:96,106,245 | C/T | — | uncertain significance |
| rs142722408 | 4:96,106,259 | C/T | — | uncertain significance |
| rs1339815696 | 4:96,106,263 | G/A | — | likely benign |
| rs765481264 | 4:96,106,274 | C/G | — | uncertain significance |
| rs151009512 | 4:96,106,321 | C/T | — | uncertain significance |
| rs2289043 | 4:96,106,322 | G/A | — | benign |
| rs563357325 | 4:96,106,328 | C/G | — | uncertain significance |
| rs111161432 | 4:96,113,367 | G/C | — | — |
| rs117896462 | 4:96,123,953 | G/C | — | benign |
| rs3733212 | 4:96,123,981 | T/C | — | benign |
| rs61736724 | 4:96,123,982 | G/A | — | likely benign |
| rs776415886 | 4:96,124,100 | C/T | — | uncertain significance |
| rs28660566 | 4:96,125,762 | C/G | — | — |
| rs141976218 | 4:96,127,798 | G/T | — | benign |
| rs146123204 | 4:96,127,799 | C/T | — | benign |
| rs761436712 | 4:96,127,844 | C/T | — | uncertain significance |
| rs2276322 | 4:96,127,869 | T/G | — | benign |
| rs139568380 | 4:96,127,874 | G/A | — | likely benign |
| rs1457720153 | 4:96,127,943 | G/T | — | uncertain significance |
| rs2621449 | 4:96,135,607 | C/A | intron variant | — |
| rs774698598 | 4:96,137,342 | C/T | — | uncertain significance |
| rs61741188 | 4:96,140,151 | C/T | — | benign |
| rs530815653 | 4:96,140,166 | A/C | — | uncertain significance |
| rs147827953 | 4:96,140,241 | C/T | — | likely benign |
| rs141315686 | 4:96,140,271 | C/T | — | likely benign |
| rs2545850227 | 4:96,140,315 | T/G | — | uncertain significance |
| rs147587723 | 4:96,140,365 | T/C | — | uncertain significance |
| rs767365642 | 4:96,140,390 | C/G | — | uncertain significance |
| rs1738377346 | 4:96,140,447 | G/C | — | uncertain significance |
| rs1243105943 | 4:96,140,450 | G/T | — | uncertain significance |
| rs377428633 | 4:96,141,199 | T/C | — | uncertain significance |
| rs780804804 | 4:96,141,282 | A/G | — | uncertain significance |
| rs12643654 | 4:96,159,817 | A/G | intron variant | — |
| rs777156310 | 4:96,163,663 | G/A | — | uncertain significance |
| rs773385589 | 4:96,166,138 | C/T | — | likely benign |
| rs1739453587 | 4:96,166,214 | G/T | — | uncertain significance |
| rs201199826 | 4:96,166,223 | C/T | — | uncertain significance |
| rs35120448 | 4:96,166,270 | T/C | — | benign |
| rs146344947 | 4:96,166,271 | G/A | — | uncertain significance |
| rs2545880333 | 4:96,171,727 | G/A | — | uncertain significance |
| rs763516412 | 4:96,171,782 | C/G | — | uncertain significance |
| rs200667278 | 4:96,199,463 | C/T | — | uncertain significance |
| rs28521922 | 4:96,203,594 | A/T | — | — |
| rs751675725 | 4:96,240,197 | T/C | — | — |
| rs2545960245 | 4:96,256,567 | T/A | — | uncertain significance |
| rs41275687 | 4:96,256,588 | C/G | — | benign |
| rs4699423 | 4:96,256,616 | A/G | — | benign |
| rs151067671 | 4:96,344,887 | T/C | intron variant | — |
| rs9307160 | 4:96,367,954 | T/C | intron variant | — |
| rs116984513 | 4:96,369,436 | T/C | intron variant | — |
| rs10856917 | 4:96,390,834 | T/C | intron variant | — |
| rs949560577 | 4:96,425,287 | C/T | — | — |
| rs35063103 | 4:96,432,154 | T/C | regulatory region variant | — |
| rs57091121 | 4:96,444,053 | A/G | — | — |
| rs61432083 | 4:96,444,058 | A/T | — | — |
| rs10032931 | 4:96,458,433 | T/G | — | — |
| rs11097470 | 4:96,467,503 | C/G | — | — |
| rs201589427 | 4:96,469,879 | C/T | — | likely benign |
| rs1217891652 | 4:96,469,971 | C/T | — | uncertain significance |
| rs372991064 | 4:96,469,983 | G/T | — | uncertain significance |
| rs764501513 | 4:96,469,999 | C/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.