USP28

ubiquitin specific peptidase 28

Summary

The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]

Known Variants58 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs141315096	11:113,670,072	C/T	—	uncertain significance
rs1485148040	11:113,670,114	C/G	—	uncertain significance
rs2547110756	11:113,670,122	C/T	—	uncertain significance
rs17115997	11:113,672,347	T/A	—	benign
rs757379676	11:113,673,896	C/T	—	uncertain significance
rs772640789	11:113,673,912	C/T	—	uncertain significance
rs1939352717	11:113,673,920	T/A	—	uncertain significance
rs903379641	11:113,673,929	C/T	—	uncertain significance
rs61760223	11:113,673,930	G/A	—	uncertain significance
rs1939360345	11:113,673,939	C/T	—	uncertain significance
rs1263702808	11:113,673,943	C/G	—	uncertain significance
rs1471718488	11:113,674,573	G/T	—	uncertain significance
rs141747464	11:113,675,444	G/A	—	uncertain significance
rs139463252	11:113,677,230	G/A	—	uncertain significance
rs773821186	11:113,677,288	T/A	—	uncertain significance
rs146774708	11:113,679,060	C/T	—	likely benign
rs201169415	11:113,679,108	G/A	—	uncertain significance
rs145072399	11:113,679,159	T/C	—	uncertain significance
rs1940545226	11:113,679,880	T/C	—	uncertain significance
rs149121605	11:113,679,889	C/T	—	uncertain significance
rs143129056	11:113,679,904	T/C	—	uncertain significance
rs138830521	11:113,679,926	C/T	—	uncertain significance
rs1940556508	11:113,679,948	C/T	—	uncertain significance
rs777100156	11:113,683,141	C/T	—	uncertain significance
rs370453360	11:113,683,180	T/G	—	uncertain significance
rs184261650	11:113,684,631	C/T	—	uncertain significance
rs766088233	11:113,685,901	A/G	—	uncertain significance
rs950466739	11:113,686,004	T/C	—	uncertain significance
rs769304445	11:113,686,012	C/T	—	uncertain significance
rs373102828	11:113,686,096	G/A	—	uncertain significance
rs758834322	11:113,688,437	A/G	—	uncertain significance
rs370812526	11:113,688,441	G/T	—	uncertain significance
rs776898061	11:113,688,493	T/A	—	uncertain significance
rs200987103	11:113,694,340	G/C	—	uncertain significance
rs746418240	11:113,694,387	T/G	—	uncertain significance
rs774912383	11:113,699,945	C/T	—	uncertain significance
rs61760221	11:113,699,955	A/C	—	likely benign
rs149747112	11:113,704,205	A/C	—	uncertain significance
rs147814422	11:113,704,206	A/G	—	uncertain significance
rs375994652	11:113,704,973	T/C	—	uncertain significance
rs200684774	11:113,704,981	C/T	—	uncertain significance
rs1944330775	11:113,705,000	T/G	—	uncertain significance
rs193920846	11:113,705,021	G/A	—	uncertain significance
rs2513580	11:113,705,340	A/G	intron variant	—
rs761993522	11:113,711,348	T/C	—	uncertain significance
rs113247986	11:113,711,448	G/A	—	uncertain significance
rs1352870162	11:113,712,449	C/T	—	uncertain significance
rs1043575007	11:113,712,485	T/C	—	uncertain significance
rs1341679481	11:113,723,226	C/T	—	uncertain significance
rs149069839	11:113,723,244	C/A	—	uncertain significance
rs1202933808	11:113,723,273	G/C	—	uncertain significance
rs367604348	11:113,723,274	T/C	—	uncertain significance
rs745596210	11:113,723,343	C/A	—	uncertain significance
rs764785803	11:113,725,006	G/A	—	uncertain significance
rs202147259	11:113,725,022	G/C	—	uncertain significance
rs535957619	11:113,744,570	A/G	—	—
rs1474202315	11:113,746,180	T/A	—	uncertain significance
rs1470420006	11:113,746,192	G/A	—	uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.