rs2513580

This is a intron variant variant in the USP28 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

substance-related disorder

Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)

Allele A

OR 7.18

p 7.0e-13

N 1,699,295

Large GWAS

multi-ancestry

About USP28

The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]

View all USP28 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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