USP34

ubiquitin specific peptidase 34

Summary

Enables cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in positive regulation of canonical Wnt signaling pathway and protein K48-linked deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants219 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs891280632	2:61,415,284	G/C	—	uncertain significance
rs184080617	2:61,415,311	G/A	—	likely benign
rs1347891163	2:61,415,313	G/A	—	uncertain significance
rs766433361	2:61,415,347	A/G	—	uncertain significance
rs2465910449	2:61,415,356	T/C	—	uncertain significance
rs200812795	2:61,415,397	T/C	—	uncertain significance
rs1489600011	2:61,415,409	G/C	—	uncertain significance
rs143842551	2:61,415,419	C/G	—	benign
rs751910261	2:61,415,466	G/C	—	uncertain significance
rs760404288	2:61,415,491	C/T	—	uncertain significance
rs14170	2:61,415,492	A/G	synonymous variant	benign
rs2465911270	2:61,415,533	C/G	—	uncertain significance
rs375896839	2:61,415,538	C/T	—	uncertain significance
rs1385334130	2:61,415,592	T/A	—	uncertain significance
rs200157293	2:61,415,784	A/G	—	uncertain significance
rs1212924477	2:61,416,188	G/C	—	uncertain significance
rs920156806	2:61,416,198	T/A	—	uncertain significance
rs571339864	2:61,417,474	A/G	—	uncertain significance
rs1230756979	2:61,417,513	T/C	—	uncertain significance
rs1686606559	2:61,417,669	G/A	—	uncertain significance
rs776785050	2:61,417,682	A/T	—	uncertain significance
rs2465921481	2:61,417,685	C/G	—	uncertain significance
rs200478528	2:61,417,714	T/C	—	uncertain significance
rs765899884	2:61,417,739	C/T	—	uncertain significance
rs753423982	2:61,417,742	C/T	—	uncertain significance
rs62151048	2:61,423,515	G/A	upstream gene variant	—
rs1442353966	2:61,430,361	T/C	—	uncertain significance
rs2465963083	2:61,430,386	C/T	—	uncertain significance
rs781541100	2:61,431,458	C/T	—	uncertain significance
rs2465966893	2:61,431,683	C/T	—	uncertain significance
rs754096886	2:61,431,704	G/T	—	uncertain significance
rs1024202260	2:61,433,170	G/A	—	uncertain significance
rs376182538	2:61,433,194	G/C	—	uncertain significance
rs2465971954	2:61,433,214	G/T	—	uncertain significance
rs1572835098	2:61,433,912	G/A	—	uncertain significance
rs1226375196	2:61,433,915	C/T	—	uncertain significance
rs758164410	2:61,433,933	G/A	—	uncertain significance
rs1199844039	2:61,436,056	C/T	—	uncertain significance
rs1687193938	2:61,436,063	A/C	—	uncertain significance
rs769149806	2:61,436,072	G/T	—	uncertain significance
rs543319914	2:61,438,992	C/G	—	uncertain significance
rs2465988454	2:61,439,037	G/C	—	uncertain significance
rs1269920170	2:61,441,408	T/C	—	likely benign
rs369458135	2:61,441,439	G/C	—	uncertain significance
rs2465997672	2:61,441,512	C/G	—	uncertain significance
rs2465997731	2:61,441,544	T/C	—	uncertain significance
rs779086203	2:61,441,644	C/A	—	uncertain significance
rs1364609646	2:61,441,691	T/C	—	uncertain significance
rs1404901391	2:61,447,465	T/C	—	uncertain significance
rs891957560	2:61,447,483	C/T	—	uncertain significance
rs2466022801	2:61,449,762	T/C	—	uncertain significance
rs567969466	2:61,450,220	C/T	—	uncertain significance
rs759732416	2:61,450,293	G/C	—	uncertain significance
rs2123111	2:61,450,454	A/G	intron variant	—
rs7570707	2:61,451,744	C/T	intron variant	—
rs3087777	2:61,454,059	T/A	intron variant	—
rs762247017	2:61,454,218	G/T	—	uncertain significance
rs1429145703	2:61,454,245	T/C	—	uncertain significance
rs1394813817	2:61,454,335	A/G	—	uncertain significance
rs2466039926	2:61,455,985	A/G	—	uncertain significance
rs771760013	2:61,456,107	A/G	—	uncertain significance
rs368019041	2:61,456,113	G/A	—	uncertain significance
rs7602859	2:61,458,206	A/T	intron variant	—
rs374438698	2:61,459,640	C/T	—	uncertain significance
rs1418731545	2:61,459,655	G/C	—	uncertain significance
rs201343724	2:61,463,044	G/C	—	uncertain significance
rs199636869	2:61,463,469	G/T	—	uncertain significance
rs72811465	2:61,468,197	T/C	intron variant	—
rs747818364	2:61,468,726	T/C	—	uncertain significance
rs776426889	2:61,468,757	T/C	—	uncertain significance
rs72884996	2:61,468,761	T/C	—	benign
rs1354865804	2:61,472,394	G/A	—	uncertain significance
rs758217282	2:61,473,492	A/G	—	uncertain significance
rs1572867915	2:61,473,573	C/G	—	uncertain significance
rs201497693	2:61,475,705	C/T	—	uncertain significance
rs377073361	2:61,475,706	G/A	—	uncertain significance
rs571807812	2:61,475,795	C/T	—	uncertain significance
rs200455302	2:61,475,796	G/A	—	uncertain significance
rs375045619	2:61,484,454	G/A	—	uncertain significance
rs10169482	2:61,486,628	G/A	—	—
rs370364642	2:61,486,864	T/C	—	likely benign
rs1219553565	2:61,486,896	T/C	—	uncertain significance
rs1306567931	2:61,492,686	G/A	—	uncertain significance
rs1386893051	2:61,493,133	G/A	—	uncertain significance
rs761146654	2:61,493,144	G/C	—	uncertain significance
rs961613651	2:61,493,151	A/G	—	uncertain significance
rs1348074648	2:61,493,194	A/C	—	uncertain significance
rs779916455	2:61,493,206	C/T	—	uncertain significance
rs2466170113	2:61,493,211	G/C	—	uncertain significance
rs760903451	2:61,493,247	C/A	—	uncertain significance
rs1489403940	2:61,493,276	G/A	—	likely benign
rs72811492	2:61,499,535	G/A	intron variant	—
rs2466220868	2:61,505,328	G/T	—	uncertain significance
rs908035514	2:61,505,383	C/T	—	uncertain significance
rs770217398	2:61,505,406	T/G	—	uncertain significance
rs200706994	2:61,505,410	G/A	—	uncertain significance
rs1689432774	2:61,505,418	C/G	—	uncertain significance
rs1424043051	2:61,505,526	C/T	—	uncertain significance
rs1315111628	2:61,507,480	C/T	—	uncertain significance
rs181465881	2:61,508,230	T/C	—	uncertain significance

Showing 100 of 219 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.