rs1024582

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

schizophrenia

Ikeda M et al. “Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.” Schizophrenia Bulletin 45(4):824-834 (2019)
Allele A
OR 1.10
p 6.0e-18
N 122,624
Large GWAS
multi-ancestry
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Research that mentions this SNP (2)

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The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population
AssociationN=1,086Liang Huang et al.(2016)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Study of 1086 Finnish infants from the CHILD-SLEEP cohort examined associations between seven CACNA1C variants previously linked to psychiatric disorders and infant sleep parameters. Three variants (rs4765913, rs4765914, rs2239063) were significantly associated with prolonged sleep latency (permuted P < 0.05), with rs2239063 showing the strongest dominant model association (beta = -0.4023, P = 0.0037). No significant associations were found with sleep duration or night awakenings.

Traits studied:Night awakeningsSleep efficiencySleep latencyTotal sleep timeWake after sleep onset
PubMedDOIMetascience Observatory
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Brain Function in Carriers of a Genome-wide Supported Bipolar Disorder Variant
FunctionalSusanne Erk et al.(2010)· Archives of General Psychiatry

A PhD dissertation investigating the cell type-specific effects of CACNA1C, a cross-disorder psychiatric risk gene encoding the α1 subunit of the L-type voltage-gated calcium channel Cav1.2. The dissertation reviews human genetic studies showing associations between multiple CACNA1C SNPs (including rs1006737, rs1024582, rs2007044) and psychiatric disorders (bipolar disorder, schizophrenia, major depression, autism), then presents preclinical studies using conditional knockout mouse models to elucidate the neurobiological mechanisms underlying these genetic associations through behavioral testing, electrophysiology, and molecular analyses.

Traits studied:Anxiety-related behaviorAutism spectrum disorderBipolar disorderBrain structure alterationsCognitive deficitsEarly life stressMajor depressionSchizophreniaStress coping behaviorWorking memory
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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