rs10401969

This is a intron variant variant in the SUGP1 gene.

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GWAS Catalog Trait Associations (34)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

total cholesterol measurement

Willer CJ et al. “Discovery and refinement of loci associated with lipid levels.” Nature Genetics 45(11):1274-1283 (2013)

Allele C

OR 0.14

p 4.0e-77

N 94,595

Large GWAS

European

Spracklen CN et al. “Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.” Human Molecular Genetics 26(9):1770-1784 (2017)

Allele C

OR 0.14

p 5.0e-75

N 219,941

Large GWAS

multi-ancestry

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele C

OR 0.06

p 2.0e-10

N 146,492

Large GWAS

East Asian

Teslovich TM et al. “Biological, clinical and population relevance of 95 loci for blood lipids.” Nature 466(7307):707-713 (2010)

Allele C

OR 4.74

p 3.0e-38

N 100,184

Large GWAS

European

Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)

Allele C

OR —

β 0.095

p 3.0e-27

N 94,674

Large GWAS

multi-ancestry

Kulminski AM et al. “Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 75(10):1811-1819 (2020)

Allele C

OR 4.53

p 5.0e-15

N 29,902

Large GWAS

European

triglyceride measurement

Allele C

OR 0.12

p 5.0e-71

N 206,044

Large GWAS

multi-ancestry

Bentley AR et al. “Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.” Nature Genetics 51(4):636-648 (2019)

Allele C

OR 0.03

p 1.0e-10

N 111,909

Large GWAS

multi-ancestry

Teslovich TM et al. “Biological, clinical and population relevance of 95 loci for blood lipids.” Nature 466(7307):707-713 (2010)

Allele C

OR 7.83

p 2.0e-29

N 96,598

Large GWAS

European

Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)

Allele C

OR 0.10

p 7.0e-38

N 94,674

Large GWAS

multi-ancestry

Willer CJ et al. “Discovery and refinement of loci associated with lipid levels.” Nature Genetics 45(11):1274-1283 (2013)

Allele C

OR 0.12

p 1.0e-69

N 94,595

Large GWAS

European

Allele C

OR 8.63

p 2.0e-14

N 29,902

Large GWAS

European

low density lipoprotein cholesterol measurement

Willer CJ et al. “Discovery and refinement of loci associated with lipid levels.” Nature Genetics 45(11):1274-1283 (2013)

Allele C

OR 0.12

p 3.0e-54

N 94,595

Large GWAS

European

Allele C

OR 0.12

p 6.0e-51

N 205,367

Large GWAS

multi-ancestry

Teslovich TM et al. “Biological, clinical and population relevance of 95 loci for blood lipids.” Nature 466(7307):707-713 (2010)

Allele C

OR 3.11

p 7.0e-22

N 95,454

Large GWAS

European

Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)

Allele C

OR —

β 0.070

p 7.0e-15

N 94,674

Large GWAS

multi-ancestry

Allele C

OR 2.95

p 3.0e-8

N 29,902

Large GWAS

European

Kathiresan S et al. “Common variants at 30 loci contribute to polygenic dyslipidemia.” Nature Genetics 41(1):56-65 (2009)

Allele C

OR —

β 0.050

p 2.0e-8

N 19,840

Large GWAS

European

Waterworth DM et al. “Genetic variants influencing circulating lipid levels and risk of coronary artery disease.” Arteriosclerosis, Thrombosis, and Vascular Biology 30(11):2264-76 (2010)

Allele C

OR 0.05

p 1.0e-11

N 17,723

Large GWAS

multi-ancestry

triglyceride measurement, C-reactive protein measurement

Ligthart S et al. “Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.” Bmc Genomics 17:443 (2016)

Allele T

OR —

p 2.0e-32

N 161,598

Large GWAS

free cholesterol in IDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.04

p 8.0e-31

N 450,015

Large GWAS

multi-ancestry

triglycerides in chylomicrons and extremely large VLDL measurement

Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)

Allele C

OR 0.09

p 9.0e-24

N 88,329

Large GWAS

European

fatty acid amount, linoleic acid measurement

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)

Allele T

OR 0.06

p 2.0e-17

N 136,016

Large GWAS

multi-ancestry

protein measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele T

OR 0.19

p 2.0e-16

N 10,708

Large GWAS

European

remnant cholesterol measurement

Li-Gao R et al. “Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism.” Diabetes 70(12):2932-2946 (2021)

Allele C

OR 0.34

p 2.0e-16

Large GWAS

apolipoprotein B measurement

Li-Gao R et al. “Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism.” Diabetes 70(12):2932-2946 (2021)

Allele C

OR 0.33

p 3.0e-16

Large GWAS

About SUGP1

SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003]

rs10401969

GWAS Catalog Trait Associations (34)

total cholesterol measurement

triglyceride measurement

low density lipoprotein cholesterol measurement

triglyceride measurement, C-reactive protein measurement

free cholesterol in IDL measurement

triglycerides in chylomicrons and extremely large VLDL measurement

fatty acid amount, linoleic acid measurement

protein measurement

remnant cholesterol measurement

apolipoprotein B measurement

About SUGP1

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