rs10402457
This is a intron variant variant in the SPC24 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
low density lipoprotein cholesterol measurement
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele C
OR 0.04
p 8.0e-45
N 355,197
Major Consortium StudyLarge GWAS
multi-ancestry
apolipoprotein B measurement
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele C
OR 0.04
p 3.0e-42
N 354,097
Major Consortium StudyLarge GWAS
multi-ancestry
total cholesterol measurement
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele C
OR 0.04
p 2.0e-35
N 355,858
Major Consortium StudyLarge GWAS
multi-ancestry
About SPC24
Predicted to contribute to microtubule binding activity. Involved in attachment of spindle microtubules to kinetochore. Located in kinetochore; nucleolus; and nucleoplasm. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Jul 2025]
View all SPC24 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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