rs10428132

This variant is located in the SCN10A gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Brugada syndrome

Bezzina CR et al. “Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.” Nature Genetics 45(9):1044-9 (2013)
Allele T
OR 2.55
p 1.0e-68
N 1,427
Large GWAS
multi-ancestry
Ishikawa T et al. “Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci.” European Heart Journal 45(26):2320-2332 (2024)
Allele T
OR 0.42
p 2.0e-38
N 2,574
Large GWAS
East Asian
Makarawate P et al. “Common and rare susceptibility genetic variants predisposing to Brugada syndrome in Thailand.” Heart Rhythm 17(12):2145-2153 (2020)
Allele T
OR 2.40
p 3.0e-10
N 586
Small GWAS
South East Asian

atrial fibrillation

Roselli C et al. “Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.” Nature Genetics 57(3):539-547 (2025)
Allele G
OR 1.06
p 5.0e-45
N 1,650,345
Meta-analysisLarge GWAS
multi-ancestry
Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele G
OR 0.01
p 2.0e-19
N 1,486,094
Large GWAS
European
Cárcel-Márquez J et al. “A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype.” Frontiers in Cardiovascular Medicine 9:940696 (2022)
Allele G
OR 0.01
p 7.0e-19
N 1,030,836
Large GWAS
European

First degree atrioventricular block

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.21
p 1.0e-33
N 620,615
Major Consortium StudyLarge GWAS
multi-ancestry

atrioventricular block

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.11
p 7.0e-21
N 617,488
Major Consortium StudyLarge GWAS
multi-ancestry

QRS duration

Swenson BR et al. “GWAS of QRS duration identifies new loci specific to Hispanic/Latino populations.” Plos One 14(6):e0217796 (2019)
Allele T
OR 0.79
p 1.0e-15
N 15,124
Large GWAS
Hispanic or Latin American
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Research that mentions this SNP (1)

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The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population
AssociationN=381Xiumin Liu et al.(2019)· Molecular Genetics &amp; Genomic Medicine

This case-control study of 381 Chinese Han patients (185 with atrial fibrillation, 196 controls) investigated associations between ion channel-related gene polymorphisms and AF risk. Three SNPs were significantly associated with AF: rs8134775 near KCNE2 conferred decreased AF risk (OR = 0.70; p = 0.034), rs35594137 in GJA5 conferred decreased AF risk in the recessive model (OR = 0.40; p = 0.018), and rs8079702 near KCNJ2 conferred increased AF risk in the recessive model (OR = 2.31; p = 0.012).

Traits studied:Atrial fibrillation
PubMedDOIMetascience Observatory

About SCN10A

The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

View all SCN10A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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