SCN10A
sodium voltage-gated channel alpha subunit 10
Summary
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Known Variants1,713 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs6599240 | 3:38,738,717 | G/A | — | benign |
| rs116283332 | 3:38,738,793 | C/T | — | likely benign |
| rs748441157 | 3:38,738,845 | G/T | — | uncertain significance |
| rs1575913891 | 3:38,738,848 | C/T | — | uncertain significance |
| rs770070419 | 3:38,738,853 | G/A | — | uncertain significance |
| rs2470547784 | 3:38,738,854 | C/A | — | uncertain significance |
| rs943619583 | 3:38,738,855 | A/G | — | likely benign |
| rs2063100183 | 3:38,738,858 | C/A | — | likely benign |
| rs1011514565 | 3:38,738,860 | G/A | — | likely benign |
| rs1243163280 | 3:38,738,865 | A/T | — | likely benign |
| rs2125978496 | 3:38,738,873 | G/A | — | likely benign |
| rs372702302 | 3:38,738,877 | T/C | — | likely benign |
| rs2063100701 | 3:38,738,884 | C/A | — | uncertain significance |
| rs2063100815 | 3:38,738,891 | T/C | — | conflicting classifications of pathogenicity |
| rs2063100895 | 3:38,738,894 | T/G | — | likely benign |
| rs2470548112 | 3:38,738,901 | G/C | — | uncertain significance |
| rs1412226048 | 3:38,738,902 | A/G | — | uncertain significance |
| rs764945982 | 3:38,738,907 | C/T | — | uncertain significance |
| rs752180138 | 3:38,738,922 | T/A | — | likely benign |
| rs755530255 | 3:38,738,923 | C/T | — | uncertain significance |
| rs781742545 | 3:38,738,930 | G/A | — | likely benign |
| rs2470548354 | 3:38,738,932 | C/T | — | uncertain significance |
| rs538064426 | 3:38,738,936 | A/C | — | likely benign |
| rs2063101667 | 3:38,738,937 | G/A | — | uncertain significance |
| rs920727914 | 3:38,738,942 | A/C | — | uncertain significance |
| rs376810032 | 3:38,738,947 | C/T | — | conflicting classifications of pathogenicity |
| rs778955408 | 3:38,738,949 | T/A | — | uncertain significance |
| rs747009227 | 3:38,738,951 | G/C | — | likely benign |
| rs145340685 | 3:38,738,954 | C/T | — | likely benign |
| rs1047449169 | 3:38,738,955 | G/A | — | uncertain significance |
| rs369390668 | 3:38,738,972 | A/G | — | likely benign |
| rs766044564 | 3:38,738,977 | C/A | — | conflicting classifications of pathogenicity |
| rs2063102378 | 3:38,738,979 | G/C | — | uncertain significance |
| rs555184897 | 3:38,738,987 | T/A | — | uncertain significance |
| rs2470548767 | 3:38,739,000 | A/G | — | uncertain significance |
| rs756547221 | 3:38,739,006 | T/G | — | uncertain significance |
| rs764330725 | 3:38,739,011 | A/T | — | uncertain significance |
| rs905568903 | 3:38,739,012 | T/C | — | uncertain significance |
| rs1265687114 | 3:38,739,013 | T/C | — | uncertain significance |
| rs1553612806 | 3:38,739,018 | G/A | — | uncertain significance |
| rs754159937 | 3:38,739,021 | A/T | — | uncertain significance |
| rs373128353 | 3:38,739,026 | A/G | — | likely benign |
| rs745954161 | 3:38,739,028 | C/A | — | uncertain significance |
| rs758434866 | 3:38,739,029 | A/G | — | likely benign |
| rs1195353680 | 3:38,739,034 | C/T | — | uncertain significance |
| rs1559405463 | 3:38,739,038 | A/G | — | likely benign |
| rs2063103684 | 3:38,739,040 | C/A | — | uncertain significance |
| rs2125978825 | 3:38,739,044 | G/T | — | likely benign |
| rs2063103746 | 3:38,739,049 | A/T | — | uncertain significance |
| rs781131021 | 3:38,739,050 | T/C | — | likely benign |
| rs2125978837 | 3:38,739,053 | A/G | — | likely benign |
| rs142653846 | 3:38,739,054 | G/A | — | likely benign |
| rs148979438 | 3:38,739,055 | C/T | — | uncertain significance |
| rs769697350 | 3:38,739,074 | C/T | — | likely benign |
| rs1245874787 | 3:38,739,076 | C/G | — | uncertain significance |
| rs2470549357 | 3:38,739,080 | T/C | — | likely benign |
| rs143523403 | 3:38,739,081 | G/A | — | conflicting classifications of pathogenicity |
| rs770710528 | 3:38,739,082 | G/A | — | uncertain significance |
| rs147660344 | 3:38,739,083 | G/C | — | likely benign |
| rs759136534 | 3:38,739,085 | T/C | — | uncertain significance |
| rs1307500570 | 3:38,739,086 | G/A | — | likely benign |
| rs767110682 | 3:38,739,090 | G/A | — | uncertain significance |
| rs776101575 | 3:38,739,094 | G/A | — | uncertain significance |
| rs559372796 | 3:38,739,095 | T/C | — | likely benign |
| rs370483003 | 3:38,739,098 | C/T | — | uncertain significance |
| rs2470549534 | 3:38,739,100 | T/C | — | uncertain significance |
| rs2063104838 | 3:38,739,104 | G/A | — | likely benign |
| rs765477377 | 3:38,739,105 | C/T | — | uncertain significance |
| rs141648641 | 3:38,739,106 | G/A | — | likely benign |
| rs1169839381 | 3:38,739,107 | G/A | — | likely benign |
| rs115463830 | 3:38,739,108 | T/G | — | likely benign |
| rs373299553 | 3:38,739,111 | A/C | — | conflicting classifications of pathogenicity |
| rs377518708 | 3:38,739,117 | T/C | — | uncertain significance |
| rs756017969 | 3:38,739,122 | C/T | — | likely benign |
| rs191869263 | 3:38,739,123 | C/T | — | conflicting classifications of pathogenicity |
| rs370779258 | 3:38,739,124 | G/A | — | uncertain significance |
| rs374422986 | 3:38,739,128 | G/C | — | likely benign |
| rs771771293 | 3:38,739,130 | C/A | — | uncertain significance |
| rs146269698 | 3:38,739,135 | T/G | — | uncertain significance |
| rs769051766 | 3:38,739,148 | C/G | — | uncertain significance |
| rs2470549951 | 3:38,739,151 | A/G | — | uncertain significance |
| rs777159266 | 3:38,739,157 | C/G | — | uncertain significance |
| rs947319524 | 3:38,739,160 | C/T | — | uncertain significance |
| rs149504103 | 3:38,739,163 | G/A | — | conflicting classifications of pathogenicity |
| rs1575914976 | 3:38,739,169 | A/G | — | uncertain significance |
| rs148537653 | 3:38,739,171 | C/T | — | conflicting classifications of pathogenicity |
| rs199503439 | 3:38,739,172 | G/A | — | uncertain significance |
| rs1001583386 | 3:38,739,175 | G/T | — | uncertain significance |
| rs147245558 | 3:38,739,188 | T/C | — | likely benign |
| rs1338861342 | 3:38,739,191 | T/G | — | uncertain significance |
| rs777591347 | 3:38,739,195 | T/C | — | uncertain significance |
| rs2470550282 | 3:38,739,202 | A/G | — | uncertain significance |
| rs1264567014 | 3:38,739,207 | G/A | — | uncertain significance |
| rs112374164 | 3:38,739,215 | A/G | — | likely benign |
| rs1253727199 | 3:38,739,223 | T/C | — | uncertain significance |
| rs1205611119 | 3:38,739,231 | T/A | — | uncertain significance |
| rs757155232 | 3:38,739,232 | C/T | — | conflicting classifications of pathogenicity |
| rs778842299 | 3:38,739,236 | C/T | — | conflicting classifications of pathogenicity |
| rs1201354997 | 3:38,739,243 | G/A | — | uncertain significance |
| rs2063107674 | 3:38,739,250 | G/A | — | likely benign |
Showing 100 of 1,713 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.