rs10453441
This variant is located in the WNT7B gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
corneal topography
Miyake M et al. “Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.” Nature Communications 6:6689 (2015)
Allele A
OR 0.05
p 3.0e-40
N 3,248
Large GWAS
multi-ancestry
central corneal thickness
Fan BJ et al. “Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus.” Investigative Ophthalmology & Visual Science 59(6):2495-2502 (2018)
Allele G
OR 3.11
p 2.0e-11
N 210
Small GWAS
multi-ancestry
Gao X et al. “Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos.” Human Molecular Genetics 25(22):5035-5045 (2016)
Allele G
OR 4.51
p 6.0e-9
N 3,584
Large GWAS
Hispanic or Latin American
C-reactive protein measurement
Han X et al. “Using Mendelian randomization to evaluate the causal relationship between serum C-reactive protein levels and age-related macular degeneration.” European Journal of Epidemiology 35(2):139-146 (2020)
Allele A
OR 0.01
p 4.0e-8
N 418,642
Large GWAS
European
About WNT7B
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]
View all WNT7B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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