rs1045430

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

major depressive disorder

Howard DM et al. “Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.” Nature Neuroscience 22(3):343-352 (2019)

Allele G

OR 1.02

p 4.0e-25

N 807,553

Meta-analysisLarge GWAS

European

Meng X et al. “Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.” Nature Genetics 56(2):222-233 (2024)

Allele G

OR 0.02

p 8.0e-12

N 1,820,689

Large GWAS

multi-ancestry

neuroticism measurement

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)

Allele T

OR 7.72

p 1.0e-14

N 449,484

Meta-analysisLarge GWAS

European

bipolar disorder, major depressive disorder

Coleman JRI et al. “The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.” Biological Psychiatry 88(2):169-184 (2020)

Allele G

OR 1.03

p 1.0e-10

N 625,026

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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