rs10750766
▶GWAS Catalog Trait Associations (95)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (95)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
reticulocyte count
Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele A
OR 0.03
p 4.0e-30
N 408,112
Large GWAS
European
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.02
p 5.0e-29
N 394,642
Large GWAS
European
Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele A
OR 0.03
p 1.0e-13
N 170,763
Large GWAS
European
triglycerides to total lipids in medium VLDL percentage
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 6.0e-30
N 450,015
Large GWAS
multi-ancestry
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele A
OR 0.03
p 3.0e-12
N 88,329
Large GWAS
European
triglycerides to total lipids in small VLDL percentage
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 2.0e-29
N 450,015
Large GWAS
multi-ancestry
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele A
OR 0.03
p 4.0e-11
N 88,329
Large GWAS
European
cholesterol to total lipids in small VLDL percentage
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 7.0e-29
N 450,015
Large GWAS
multi-ancestry
systolic blood pressure
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.03
p 2.0e-28
N 425,750
Major Consortium StudyLarge GWAS
European
cholesterol to total lipids in very large VLDL percentage
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 3.0e-26
N 450,015
Large GWAS
multi-ancestry
cholesteryl esters to total lipids in very large VLDL percentage
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 3.0e-26
N 450,015
Large GWAS
multi-ancestry
free cholesterol to total lipids in small LDL percentage
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 4.0e-25
N 450,015
Large GWAS
multi-ancestry
triglycerides to total lipids in large LDL percentage
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 2.0e-24
N 450,015
Large GWAS
multi-ancestry
cholesteryl esters to total lipids in small VLDL percentage
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 3.0e-24
N 450,015
Large GWAS
multi-ancestry
▶Research that mentions this SNP (1)
▶lncRNA Neat1 Stimulates Osteoclastogenesis Via Sponging miR-7FunctionalN=426,824Yan Zhang et al.(2020)· Journal of Bone and Mineral Research
lncRNA Neat1 Stimulates Osteoclastogenesis Via Sponging miR-7
FunctionalN=426,824Yan Zhang et al.(2020)· Journal of Bone and Mineral Research
This functional study establishes that the long noncoding RNA NEAT1 stimulates osteoclastogenesis via sponging miR-7, relieving inhibition of PTK2 expression. A distal GWAS SNP rs12789028 functions as an allele-specific enhancer regulating NEAT1 expression; the G-allele increases NEAT1 expression leading to enhanced bone resorption and osteoporosis risk. The mechanism links a NEAT1 locus variant to bone mineral density through lncRNA-mediated osteoclastogenesis.
Traits studied:Bone mineral densityBone resorptionOsteoclastogenesisOsteoporosis
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…