rs10776752

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele T

OR 0.73

p 7.0e-56

N 1,028,980

Large GWAS

multi-ancestry

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele T

OR 0.04

p 7.0e-44

N 1,212,859

Large GWAS

European

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele T

OR 0.81

p 6.0e-32

N 526,001

Large GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.03

p 8.0e-18

N 394,642

Large GWAS

European

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele T

OR 0.64

p 5.0e-14

N 130,777

Large GWAS

multi-ancestry

diastolic blood pressure

Allele T

OR 0.42

p 9.0e-50

N 1,028,980

Large GWAS

multi-ancestry

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele T

OR 0.04

p 3.0e-41

N 1,212,859

Large GWAS

European

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele T

OR 0.47

p 1.0e-32

N 526,001

Large GWAS

European

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele T

OR 0.34

p 2.0e-10

N 130,777

Large GWAS

multi-ancestry

hypertension

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.10

p 5.0e-25

N 394,626

Large GWAS

European

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele T

OR 0.13

p 3.0e-18

N 50,792

Large GWAS

multi-ancestry

pulse pressure measurement

Allele T

OR 0.33

p 8.0e-24

N 1,028,980

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.02

p 6.0e-13

N 506,308

Large GWAS

multi-ancestry

Beta blocking agent use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.08

p 4.0e-16

N 402,750

Large GWAS

multi-ancestry

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele T

OR 0.10

p 6.0e-11

N 224,024

Major Consortium StudyLarge GWAS

European

mean arterial pressure

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele T

OR 0.44

p 1.0e-13

N 130,777

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs10776752

GWAS Catalog Trait Associations (6)

systolic blood pressure

diastolic blood pressure

hypertension

pulse pressure measurement

Beta blocking agent use measurement

mean arterial pressure

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